Effector ExoU from the type III secretion system is an important modulator of gene expression in lung epithelial cells in response to Pseudomonas aeruginosa infection.

@article{McMorran2003EffectorEF,
  title={Effector ExoU from the type III secretion system is an important modulator of gene expression in lung epithelial cells in response to Pseudomonas aeruginosa infection.},
  author={Brendan J McMorran and Liushi Town and Elaine O. Costelloe and James Henry Stuart Palmer and C. Jay Engel and David A. Hume and Brandon J. Wainwright},
  journal={Infection and immunity},
  year={2003},
  volume={71 10},
  pages={
          6035-44
        }
}
Pseudomonas aeruginosa is an important pathogen in immunocompromised patients and secretes a diverse set of virulence factors that aid colonization and influence host cell defenses. An important early step in the establishment of infection is the production of type III-secreted effectors translocated into host cells by the bacteria. We used cDNA microarrays to compare the transcriptomic response of lung epithelial cells to P. aeruginosa mutants defective in type IV pili, the type III secretion… CONTINUE READING

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