Effectiveness of the selective D4 antagonist sonepiprazole in schizophrenia: a placebo-controlled trial

@article{Corrigan2004EffectivenessOT,
  title={Effectiveness of the selective D4 antagonist sonepiprazole in schizophrenia: a placebo-controlled trial},
  author={Mark H. Corrigan and Christopher C. Gallen and Maria Luisa Bonura and Kalpana Merchant},
  journal={Biological Psychiatry},
  year={2004},
  volume={55},
  pages={445-451}
}
View on Elsevier
doi.org
96 Citations
Background Citations
33
Results Citations
2

96 Citations

Efficacy of second-generation-antipsychotics in the treatment of negative symptoms of schizophrenia: a meta-analysis of randomized clinical trials.

Role of dopamine D(2) receptors for antipsychotic activity.

TLDR
This review summarizes the current state of knowledge and presents some critical clinical considerations regarding the mechanisms linking dopamine disturbance to the expression of psychosis and its blockade to the progressive resolution of psychosis, keeping in perspective the speed and onset of antipsychotic action.

Pharmacological treatment of schizophrenia: a critical review of the pharmacology and clinical effects of current and future therapeutic agents

TLDR
An update and critical review of the pharmacology and clinical profiles of current antipsychotic drugs and drugs acting on novel targets with potential to be therapeutic agents in the future is provided.

Experimental studies on novel pharmacological strategies in the treatment of schizophrenia

TLDR
Investigating the effects of adjunctive treatment with either a low dose of L-dopa or topiramate to low doses of the selective DA D2 receptor antagonist raclopride using the conditioned avoidance response (CAR) paradigm concluded that an enhanced prefrontal DA output per se may serve to improve the effect of typical APDs in schizophrenia.

Neurochemical arguments for the use of dopamine D4 receptor stimulation to improve cognitive impairment associated with schizophrenia

Efficacy of second-generation-antipsychotics in the treatment of negative symptoms of schizophrenia: A meta-analysis of randomized clinical trials

The past and future of novel, non-dopamine-2 receptor therapeutics for schizophrenia: A critical and comprehensive review.

Dopamine Receptors and the Treatment of Schizophrenia

TLDR
This chapter reviews the pharmacological effects of typical and atypical antipsychotics on the different dopamine receptor subtypes, as well as on non-dopaminergic receptor targets, and on the prominent role of D2 receptor blockade as the primary site of their action in brain.

Strategies for pharmacotherapy of schizophrenia

TLDR
Various strategies to improve cortical function are described, which is believed to be suboptimal in patients with cognitive deficits and negative symptoms, which include drug actions on dopamine, 5-HT, norepinephrine, nicotinic and muscarinic receptor subtypes, as well as various glutamatergic drug targets.

Drugs in development for the treatment of schizophrenia

  • R. Emsley
  • Psychology, Medicine
    Expert opinion on investigational drugs
  • 2009
TLDR
An up-to-date review of antipsychotic drugs currently in development, focusing on the findings to date for compounds that are presently in Phase III clinical trials, suggests several drugs in early development have great potential.
...

References

SHOWING 1-10 OF 22 REFERENCES

The effects of a selective D4 dopamine receptor antagonist (L-745,870) in acutely psychotic inpatients with schizophrenia. D4 Dopamine Antagonist Group.

TLDR
The selective D4 dopamine receptor antagonist L-745,870 was ineffective as an antipsychotic for the treatment of neuroleptic responsive inpatients with acute schizophrenia.

Pharmacological characterization of U-101387, a dopamine D4 receptor selective antagonist.

TLDR
The results demonstrate that the D4-selective antagonist, U-101387, produces effects that are distinct from those of the nonselective D2 antagonists as well as D3-preferring agents.

Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine.

TLDR
In this relatively brief study, the apparently increased comparative risk of agranulocytosis requires that the use of clozapine be limited to selected treatment-resistant patients.

Localization of dopamine D4 receptors in GABAergic neurons of the primate brain

TLDR
It is suggested that clozapine's beneficial effects in schizophrenia may be achieved, in part, through D4-mediated GABA modulation, possibly implicating disinhibition of excitatory transmission in intrinsic cortical, thalamocortical and extrapyramidal pathways.

The Selective Dopamine D4 Receptor Antagonist, PNU-101387G, Prevents Stress-Induced Cognitive Deficits in Monkeys

Distribution of putative D4 dopamine receptors in postmortem striatum from patients with schizophrenia

  • A. MurrayT. Hyde J. Kleinman
  • Biology, Psychology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1995
TLDR
These findings suggest that the putative D4 receptors are not synthesized in this region, but are presynaptically localized on striatal afferent terminals, which is inconsistent with mRNA studies that have shown negligible amounts in striatum and accumbens.

Dopamine D4 receptors elevated in schizophrenia

TLDR
It is concluded that the combined density of D2 and D3 receptors (labelled by [3H]raclopride) is increased by only 10% in schizophrenia brain, as found by Farde et al.15, but that it is the density of dopamine D4 receptors which is sixfold elevated in schizophrenia.

The role of dopamine D4 receptor in the induction of behavioral sensitization to amphetamine and accompanying biochemical and molecular adaptations.

TLDR
D dopamine D4 receptors play an important role in the induction of behavioral sensitization to Amp and accompanying adaptations in pre- and postsynaptic neural systems associated with the mesolimbocortical dopamine projections, and concurrent administration of PNU-101387G with Amp during pretreatment blocked the augmentation in Amp-induced dopamine release.

Dopamine D4 receptors and effects of guanine nucleotides on [3H]raclopride binding in postmortem caudate nucleus of subjects with schizophrenia or major depression

Clozapine and haloperidol block the induction of behavioral sensitization to amphetamine and associated genomic responses in rats.