Effectiveness of the selective D4 antagonist sonepiprazole in schizophrenia: a placebo-controlled trial

  title={Effectiveness of the selective D4 antagonist sonepiprazole in schizophrenia: a placebo-controlled trial},
  author={M. Corrigan and C. Gallen and M. Bonura and K. Merchant and Sonepiprazole Study Group},
  journal={Biological Psychiatry},
  • M. Corrigan, C. Gallen, +2 authors Sonepiprazole Study Group
  • Published 2004
  • Psychology, Medicine
  • Biological Psychiatry
  • BACKGROUND Selective localization of dopamine D(4) receptors in the prefrontal cortex and preferential affinity of clozapine for the dopamine D(4) receptor over the D(2) receptor led to the hypothesis that the superior efficacy of clozapine may be mediated via blockade of the D(4) receptor. This hypothesis was tested by evaluating sonepiprazole, a selective D(4) dopamine antagonist, in schizophrenia patients. METHODS We treated 467 hospitalized schizophrenia patients with scores of > or = 60… CONTINUE READING
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