Effectiveness of rifampin, rifabutin, and rifapentine for preventive therapy of tuberculosis in mice.

@article{Ji1993EffectivenessOR,
  title={Effectiveness of rifampin, rifabutin, and rifapentine for preventive therapy of tuberculosis in mice.},
  author={Baohong Ji and Chantal Truffot-Pernot and Christian Lacroix and Mario.C. Raviglione and Richard J. O'Brien and Piero Olliaro and Giorgio Roscigno and Jacques H. Grosset},
  journal={The American review of respiratory disease},
  year={1993},
  volume={148 6 Pt 1},
  pages={1541-6}
}
To identify alternative regimens for preventive therapy of tuberculosis, the pharmacokinetics and antimicrobial activities of rifampin (RMP), rifabutin (RBT), and rifapentine (RPT) were compared in BCG-vaccinated and M. tuberculosis-infected immunocompetent mice. RPT showed the highest serum peak level (Cmax) and the longest half-life (t1/2), whereas RBT displayed the lowest Cmax and the shortest t1/2. On weight-to-weight basis, both RPT and RBT were more bactericidal than RMP. The activity of… CONTINUE READING

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