Effectiveness of paracetamol versus ibuprofen administration in febrile children: A systematic literature review

@article{Narayan2017EffectivenessOP,
  title={Effectiveness of paracetamol versus ibuprofen administration in febrile children: A systematic literature review},
  author={Kaajal Narayan and Simon Cooper and Julia Morphet and Kelli Innes},
  journal={Journal of Paediatrics and Child Health},
  year={2017},
  volume={53}
}
The use of antipyretics to manage the febrile child is becoming increasingly popular. Paracetamol and ibuprofen are the most commonly used interventions to manage fever in children; however, there have been no comparative analyses. The aim of the study is to evaluate the evidence comparing paracetamol to ibuprofen in the treatment of fever in children. 
Prescribing Controversies: An Updated Review and Meta-Analysis on Combined/Alternating Use of Ibuprofen and Paracetamol in Febrile Children
TLDR
Findings are not robust enough to encourage combined or alternating paracetamol and ibuprofen instead of monotherapy to treat febrile children, reinforcing the current recommendation of most of the international guidelines.
Comparative evaluation of the efficacy of intravenous paracetamol and ibuprofen on the treatment of tonsillopharyngitis with fever: A prospective, randomized controlled, double-blind clinical trial
OBJECTIVE: Tonsillopharyngitis is one of the constituents of upper respiratory tract infection (URTI). Fever is a URTI symptom requiring treatment due to the occurrence of discomfort and high
Ibuprofen in the treatment of children's inflammatory pain: a clinical and pharmacological overview.
TLDR
Ibuprofen showed a good safety profile and provided evidence of effectiveness for mild-moderate pain of different origin in children, and remains the treatment of choice for pain in chronic inflammatory diseases such as arthritis.
Symptomatic fever management in children: A systematic review of national and international guidelines
TLDR
There is no recommendation on which all guidelines agree, and many are inconsistent with the evidence–this is true even for recent guidelines.
Symptomatic fever management in children: A systematic review of national and international guidelines
TLDR
There is no recommendation on which all guidelines agree, and many are inconsistent with the evidence – this is true even for recent guidelines.
Management of acute fever in children: Consensus recommendations for community and primary healthcare providers in sub-Saharan Africa
  • R. Green, D. Webb, +7 authors F. Mustafa
  • Medicine
    African journal of emergency medicine : Revue africaine de la medecine d'urgence
  • 2021
TLDR
This multidisciplinary consensus guide was developed to assist pharmacists and primary healthcare workers in sub-Saharan Africa to risk stratify and manage children who present with fever, decide when to refer, and how to advise parents and caregivers.
Bénéfices et risques de l’ibuprofène chez les enfants fébriles : revue systématique de la littérature en vue de la réalisation d’un outil écrit d’information à destination des patients
TLDR
A systematic review of systematic literature reviews to look for data on the benefits and risks of ibuprofen compared to placebo, paracetamol or a treatment alternating or combining par acetamol and ib uprofen in children with fever in children aged 0-18 years found no evidence of improved child comfort.
Léčba horečky u dětí
Horecka je symptom, který provazi řadu onemocněni. Některa z nich jsou casta, jina naopak raritni. V praxi se horecka běžněvyskytuje jako přiznak viroveho nebo bakterialniho onemocněni ditěte.
Intravenous paracetamol: Features and applications
Kindernotfälle
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References

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A randomised open label study of the combined use of paracetamol and ibuprofen to rapidly reduce fever is reported. The advantage of using both medications is less than half a degree centigrade in
Fever management: evaluating the use of ibuprofen and paracetamol.
TLDR
A literature search of randomised controlled trials carried out to identify which, if either, of these drugs is faster at reducing a fever found ibuprofen to be marginally more effective than paracetamol.
Paracetamol plus ibuprofen reduced fever in young children faster than paracetamol alone but not ibuprofen alone
Paracetamol plus ibuprofen reduced fever in young children faster than paracetamol alone but not ibuprofen alone
Paracetamol and Ibuprofen for Paediatric Pain and Fever
To review the literature on the pharmacology and pharmacokinetics of paracetamol and ibuprofen pertaining to their use for paediatric pain and fever.
Effectiveness and tolerability of ibuprofen-arginine versus paracetamol in children with fever of likely infectious origin.
TLDR
Based on the present results, ibuprofen-arginine oral drops have shown to be a safe, well-tolerated and potent paediatric antipyretic agent and should be considered as an adequate choice for the control of paediatric fever of likely infectious aetiology.
Effectiveness and tolerability of ibuprofen‐arginine versus paracetamol in children with fever of likely infectious origin
TLDR
Overall efficacy was judged from the recovery or improvement in 68.8% of patients in the ibuprofen‐arginine group compared with 65.5% in the paracetamol group, although this was not statistically significant, a trend towards improved activity was observed.
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TLDR
The use of paracetamol in therapeutic doses generally is safe, although hepatotoxicity has occurred with recommended dosages in children and in developing countries where malnutrition is common, data on the safety of par acetamol are lacking.
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TLDR
Trial evidence that paracetamol has a superior antipyretic effect than placebo is inconclusive and there is insufficient evidence to show whether par acetamol influenced the risk of febrile convulsions.
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TLDR
Parents, nurses, pharmacists, and doctors wanting to use medicines to supplement physical measures to maximise the time that children spend without fever should use ibuprofen first and consider the relative benefits and risks of using paracetamol plus ib uprofen over 24 hours.
Paracetamol for treating fever in children.
TLDR
Trial evidence that paracetamol has a superior antipyretic effect than placebo is inconclusive and there is insufficient evidence to show whether par acetamol influenced the risk of febrile convulsions.
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