Effectiveness of nitrofuran derivatives in sensitizing hypoxic mammalian cells to x rays.

@article{Chapman1973EffectivenessON,
  title={Effectiveness of nitrofuran derivatives in sensitizing hypoxic mammalian cells to x rays.},
  author={J. D. Chapman and A. P. Reuvers and J. Borsa},
  journal={The British journal of radiology},
  year={1973},
  volume={46 548},
  pages={
          623-30
        }
}
Abstract Various nitrofuran derivatives have been tested with Chinese hamster cells growing in vitro to determine their toxicity and radiosensitizing effectiveness. All nitrofurans tested displayed a greater radiosensitizing potential than p-nitroacetophenone for hypoxic cells at concentrations producing no acute toxicity. The most effective compound tested to date is nifuraldezone which at 250 μm in complete medium gives the same extent of radiosensitization (ER∼2·85) as oxygen in air… Expand
Ro-07-0582 as a radiosensitizer and cytotoxic agent.
  • E. Hall, J. Biaglow
  • Medicine
  • International journal of radiation oncology, biology, physics
  • 1977
A 3-nitro triazole as a hypoxic cell sensitizer.
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