Effectiveness of myoinositol for polycystic ovary syndrome: a systematic review and meta-analysis

  title={Effectiveness of myoinositol for polycystic ovary syndrome: a systematic review and meta-analysis},
  author={Liuting Zeng and Kailin Yang},
PurposeTo assess the effectiveness and safety of myoinositol for patients with PCOS.MethodsIn this meta-analysis, data from randomized controlled trials are obtained to assess the effects of myoinositol vs. placebo or western medicine in women with PCOS. The study’s registration number is CRD42017064563. The primary outcomes included total testosterone, estradiol (E2) and the homeostatic model assessment (HOMA) of insulin resistance.ResultTen trials involving 573 patients were included. The… 

Myo-inositol in polycystic ovary syndrome: a systematic review and positioning of its use

Myo-inositol improves clinical and laboratory parameters in both pregnant and non-pregnant PCOS patients, increasing the fertility rate and improving pregnancy outcomes, and one of the mechanisms that explain the emergence of metabolic and reproductive changes in women with PCOS.

Effects of nutrition on metabolic and endocrine outcomes in women with polycystic ovary syndrome: an umbrella review of meta-analyses of randomized controlled trials.

There was no high-certainty evidence that diets alone in women with PCOS improved health or reproductive outcomes, and Supplementation with vitamin D, probiotics/synbiotics, omega-3, inositol, and curcumin showed favorable effects on some metabolic outcomes.

Efficacy of Myo-inositol on Anthropometric, Metabolic, and Endocrine Outcomes in PCOS Patients: a Meta-analysis of Randomized Controlled Trial

Clinically significant improvement was not observed in anthropometric, metabolic, and endocrine outcomes after myo-inositol treatment in PCOS patients, and heterogeneity between studies was high.

Impact of myoinositol with metformin and myoinositol alone in infertile PCOS women undergoing ovulation induction cycles - randomized controlled trial

  • P. PrabhakarR. Mahey N. Bhatla
  • Medicine, Biology
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • 2020
Myoinositol (4 g) might be used alone as an insulin sensitizer to improve metabolic, hormonal and reproductive outcome in infertile PCOS women.

Polycystic ovary syndrome and type 2 diabetes mellitus: A state-of-the-art review

Adoption of a healthy lifestyle with adherence to improved dietary patterns, avoidance of consumption of endocrine-disrupting foods and beverages, regular exercise, and the effect of certain medications, such as metformin and glucagon-like peptide 1 receptor agonists, are discussed.

Does the combination of myo-inositol improve pregnancy outcomes in obese polycystic ovary syndrome women undergoing ovarian stimulation with clomiphene citrate?

Compared to ovarian stimulation with CC alone, the combination provides a beneficial effect on endometrial thickness and the number of mature follicles, however, ovulation rates are similar with the two regimens.

Experts’ opinion on inositols in treating polycystic ovary syndrome and non-insulin dependent diabetes mellitus: a further help for human reproduction and beyond

The evidence suggests that MI, alone or with DCI in the 40:1 ratio, offers a promising treatment for PCOS and NIDDM.

Improvement of Insulin Sensitivity Increases Pregnancy Rate in Infertile PCOS Women: A Systemic Review

Nonsurgical therapeutic strategies that promote superior IS improvement may aid infertile PCOS women to increase their possibility of successful pregnancy regardless of the various interventions.

Inositols in Polycystic Ovary Syndrome: An Overview on the Advances

Current treatment for Polycystic Ovary Syndrome: focus on adolescence.

Emerging data support inositol and alpha-lipoic acid as alternative compounds, alone or in combination with the aforementioned strategies, with favourable effects on ovulation, insulin resistance and inflammation, and additional studies are required in adolescents, in order to assess the effectiveness of diet supplements in preventing negative impacts of PCOS on fertility in adult age.



Effects of myo-inositol in women with PCOS: a systematic review of randomized controlled trials

An overview on the clinical outcomes of the MYO use as a treatment to improve ovarian function and metabolic and hormonal parameters in women with PCOS is provided.

Effects of Inositol(s) in Women with PCOS: A Systematic Review of Randomized Controlled Trials

This systematic review is the analysis of recent randomized clinical trials of inositol(s) in PCOS, in particular myo- and D-chiro-inositol, in order to better elucidate their physiological involvement inPCOS and potential therapeutic use, alone and in conjunction with assisted reproductive technologies, in the clinical treatment of women with PCOS.


There was a definite improvement in biochemical profile with both metformin and myo-inositol in the armamentarium for the treatment of PCOS, indicating that this syndrome may be related to the higher incidence of metabolic syndrome in this population.

Endocrine and clinical effects of myo-inositol administration in polycystic ovary syndrome. A randomized study

  • P. ArtiniO. M. Di Berardino V. Cela
  • Medicine, Biology
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • 2013
Myo-inositol administration improves reproductive axis functioning in PCOS patients reducing the hyperinsulinemic state that affects LH secretion, and insulin sensitivity, expressed as glucose-to-insulin ratio and HOMA index resulted significantly improved after 12 weeks of treatment.

Metabolic and hormonal effects of myo-inositol in women with polycystic ovary syndrome: a double-blind trial.

Treatment of PCOS patients with Myo-inositol provided a decreasing of circulating insulin and serum total testosterone as well as an improvement in metabolic factors.

Myo-Inositol in the Treatment of Teenagers Affected by PCOS

Administration of MI is a safe and effective method to prevent and correct metabolic disorders in teenagers affected by PCOS and with combination of MI and OCPs antiandrogenic effects are enhanced, negative impact of O CPs on weight gain is balanced, and metabolic profile is improved.

Comparison of two insulin sensitizers, metformin and myo-inositol, in women with polycystic ovary syndrome (PCOS)

The two insulin-sensitizers, metformin and myo-inositol, show to be useful in PCOS women in lowering BMI and ameliorating insulin sensitivity, and improving menstrual cycle without significant differences between the two treatments.

Association between High Serum Homocysteine Levels and Biochemical Characteristics in Women with Polycystic Ovarian Syndrome: A Systematic Review and Meta-Analysis

High homocysteine levels in women with PCOS are not related to degree of obesity, IR, or androgen levels, and metformin treatment cannot decrease the homocystine levels.

Effects of inositol on ovarian function and metabolic factors in women with PCOS: a randomized double blind placebo-controlled trial.

A beneficial effect of inositol in improving ovarian function in women with oligomenorrhea and polycystic ovaries is found and the inverse relationship between body mass of the patients and the efficacy of the treatment is found.