Effectiveness of minocycline in acute white matter injury after intracerebral hemorrhage.

@article{Zou2017EffectivenessOM,
  title={Effectiveness of minocycline in acute white matter injury after intracerebral hemorrhage.},
  author={Xiang Zou and Zehan Wu and Wei Zhu and Liang Chen and Ying Mao and Fan Zhao},
  journal={Journal of neurosurgery},
  year={2017},
  volume={126 6},
  pages={1855-1862}
}
OBJECTIVE Intracerebral hemorrhage (ICH) is a fatal disease with high morbidity and mortality, which may be followed by white matter injury (WMI) due to the local oxidizing reaction induced by iron (Fe). In this study, the authors examined the effect of the tetracycline antibiotic minocycline on Fe-induced WMI and c-Jun N-terminal kinase (JNK) activation in rats. METHODS Thirty-six male Sprague-Dawley rats underwent an intracaudate injection of saline, Fe, or Fe + minocycline. Another 36 rats… CONTINUE READING