Effectiveness of intra-articular hyaluronan (Synvisc, hylan G-F 20) for the treatment of first metatarsophalangeal joint osteoarthritis: a randomised placebo-controlled trial.

@article{Munteanu2011EffectivenessOI,
  title={Effectiveness of intra-articular hyaluronan (Synvisc, hylan G-F 20) for the treatment of first metatarsophalangeal joint osteoarthritis: a randomised placebo-controlled trial.},
  author={Shannon E. Munteanu and Gerard V Zammit and Hylton B. Menz and Karl B Landorf and Christopher J. Handley and Ayman Elzarka and Jason Deluca},
  journal={Annals of the rheumatic diseases},
  year={2011},
  volume={70 10},
  pages={1838-41}
}
OBJECTIVES To evaluate the effectiveness of a single intra-articular injection of hylan G-F 20 (Synvisc) for symptomatic first metatarsophalangeal joint (MTPJ) osteoarthritis (OA). METHODS Participants (n = 151) with symptomatic first MTPJ OA were randomly allocated to receive up to 1 ml intra-articular injection of either hylan G-F 20 or placebo (saline). Participants and assessors were blinded. Outcomes were evaluated at 1, 3 and 6 months after injection. The primary outcome measurement was… CONTINUE READING

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