Effectiveness of interventions to manage acute malnutrition in children under 5 years of age in low‐ and middle‐income countries: A systematic review

  title={Effectiveness of interventions to manage acute malnutrition in children under 5 years of age in low‐ and middle‐income countries: A systematic review},
  author={Jai K Das and Rehana A Salam and Marwah Saeed and Faheem Ali Kazmi and Zulfiqar A. Bhutta},
  journal={Campbell Systematic Reviews},

Measurement of benefits in economic evaluations of nutrition interventions in low‐ and middle‐income countries: A systematic review

This systematic review summarises literature on the interventions, sectors, benefit terminology and benefit types included in cost‐effectiveness, cost‐utility and benefit‐cost analyses (CEA, CUA and BCA, respectively) of nutrition interventions in low‐ and middle‐income countries.



Ready-to-use therapeutic food (RUTF) for home-based nutritional rehabilitation of severe acute malnutrition in children from six months to five years of age.

The main outcomes were recovery, deterioration or relapse and mortality as primary outcomes; and rate of weight gain, time to recovery, anthropometrical changes, cognitive development and function, adverse outcomes and acceptability as secondary outcomes.

Locally prepared ready to use therapeutic food for the treatment of children with severe acute malnutrition: a randomized controlled trial

As per the WHO 's guidelines for the inpatient management of Severe acute malnutrition children, after initial stabilization phase where the acute medical conditions like hypoglycaemia, hypothermia,

Treatment outcome in patients with severe acute malnutrition managed with protocolised care at malnutrition treatment corner in Rajasthan, India: a prospective observational study (quasi-experimental)

Severely malnourished children have a better weight gain and improvement in nutritional status while receiving protocolised care in malnutrition treatment corner, which results in faster recovery because it is well accepted and better tolerated.

Community management of acute malnutrition (CMAM) programme in Pakistan effectively treats children with uncomplicated severe wasting

Pakistan's CMAM programme is effective in achieving good survival and recovery rates and population‐level impact could be increased by giving priority to children 6–23 months old and children with multiple anthropometric failure and by scaling up CMAM in the provinces and areas where the risk, prevalence, and/or burden of severe acute malnutrition is highest.

Amino-acid-enriched cereals ready-to-use therapeutic foods (RUTF) are as effective as milk-based RUTF in recovering essential amino acid during the treatment of severe acute malnutrition in children: An individually randomized control trial in Malawi

Findings indicate that treatment with either of the 3 RUTFs was associated with adequate protein synthesis and that all the formulations provided sufficient functional metabolites of plasma amino acids to support nutritional recovery from SAM.

Effectiveness of a Locally Produced, Fish-Based Food Product on Weight Gain among Cambodian Children in the Treatment of Acute Malnutrition: A Randomized Controlled Trial

The ability to draw conclusions was limited by lower weight gain than the desired 4 g/kg/day in both groups, no superiority was found for either RUTF.

Guidelines for the treatment of severe acute malnutrition: a systematic review of the evidence for antimicrobial therapy

Current evidence supports the continued use of broad-spectrum oral amoxicillin for treating children with uncomplicated SAM as outpatients and there is no strong evidence to justify changing the current parenteral therapy guidelines for children admitted with complicated SAM.

Severe and Moderate Acute Malnutrition Can Be Successfully Managed with an Integrated Protocol in Sierra Leone.

Integrated management of GAM in children is an acceptable alternative to standard management and provides greater community coverage, according to objective.

A ready-to-use therapeutic food containing 10% milk is less effective than one with 25% milk in the treatment of severely malnourished children.

Treating children with SAM with 10% milk RUTF with soy is less effective compared with treatment with the standard 25% Milk RUTF, and clinical evidence should be examined before recommending any changes to the formulation of RUTF.