Effectiveness of interventions to manage acute malnutrition in children under 5 years of age in low‐ and middle‐income countries: A systematic review

  title={Effectiveness of interventions to manage acute malnutrition in children under 5 years of age in low‐ and middle‐income countries: A systematic review},
  author={Jai K Das and Rehana A Salam and Marwah Saeed and Faheem Ali Kazmi and Zulfiqar A. Bhutta},
  journal={Campbell Systematic Reviews},


Ready-to-use therapeutic food (RUTF) for home-based nutritional rehabilitation of severe acute malnutrition in children from six months to five years of age.
The main outcomes were recovery, deterioration or relapse and mortality as primary outcomes; and rate of weight gain, time to recovery, anthropometrical changes, cognitive development and function, adverse outcomes and acceptability as secondary outcomes.
Amino-acid-enriched cereals ready-to-use therapeutic foods (RUTF) are as effective as milk-based RUTF in recovering essential amino acid during the treatment of severe acute malnutrition in children: An individually randomized control trial in Malawi
Findings indicate that treatment with either of the 3 RUTFs was associated with adequate protein synthesis and that all the formulations provided sufficient functional metabolites of plasma amino acids to support nutritional recovery from SAM.
Community management of acute malnutrition (CMAM) programme in Pakistan effectively treats children with uncomplicated severe wasting
Pakistan's CMAM programme is effective in achieving good survival and recovery rates and population‐level impact could be increased by giving priority to children 6–23 months old and children with multiple anthropometric failure and by scaling up CMAM in the provinces and areas where the risk, prevalence, and/or burden of severe acute malnutrition is highest.
Effectiveness of a Locally Produced, Fish-Based Food Product on Weight Gain among Cambodian Children in the Treatment of Acute Malnutrition: A Randomized Controlled Trial
The ability to draw conclusions was limited by lower weight gain than the desired 4 g/kg/day in both groups, no superiority was found for either RUTF.
Guidelines for the treatment of severe acute malnutrition: a systematic review of the evidence for antimicrobial therapy
Current evidence supports the continued use of broad-spectrum oral amoxicillin for treating children with uncomplicated SAM as outpatients and there is no strong evidence to justify changing the current parenteral therapy guidelines for children admitted with complicated SAM.
  • 2017
Effectiveness of food supplements in increasing fat-free tissue accretion in children with moderate acute malnutrition: A randomised 2 × 2 × 3 factorial trial in Burkina Faso
Based on this study, children with MAM mainly gain fat-free tissue when rehabilitated and current LNSs with DS may be improved by shifting to SI, and the role of milk relative to soy merits further research.
Effectiveness of supplementary blended flour based on chickpea and cereals for the treatment of infants with moderate acute malnutrition in Iran: A randomized clinical trial
This study showed that Shadameen in combination with multivitamin/mineral and counselling therapy can be more effective in decreasing the wasting rate of children with MAM than vitamin/Mineral and counseling therapy alone.
Effectiveness of three commonly used transition phase diets in the inpatient management of children with severe acute malnutrition: a pilot randomized controlled trial in Malawi
This pilot trial does not demonstrate that a particular transition phase diet is significantly better or worse since biochemical and clinical outcomes in children with SAM did not differ, however, larger and more tightly controlled efficacy studies are needed to confirm these findings.
Locally prepared ready to use therapeutic food for the treatment of children with severe acute malnutrition: a randomized controlled trial
As per the WHO 's guidelines for the inpatient management of Severe acute malnutrition children, after initial stabilization phase where the acute medical conditions like hypoglycaemia, hypothermia,