Effectiveness of infliximab in refractory FDG PET-positive sarcoidosis.

@article{Vorselaars2015EffectivenessOI,
  title={Effectiveness of infliximab in refractory FDG PET-positive sarcoidosis.},
  author={Adriane D. M. Vorselaars and Heleen A. Crommelin and Vera H M Deneer and Bob Meek and Anke M E Claessen and Ruth G M Keijsers and Coline HM van Moorsel and Jan C. Grutters},
  journal={The European respiratory journal},
  year={2015},
  volume={46 1},
  pages={175-85}
}
Inconclusive evidence for the efficacy of infliximab in sarcoidosis hinders the global use of this potentially beneficial drug. To study infliximab efficacy in a clinical setting, we performed a prospective open-label trial in patients refractory to conventional treatment. Patients (n=56) received eight infusions of 5 mg·kg(-1) infliximab. Pulmonary function, disease activity measured by (18)F-fluorodeoxyglucose (FDG) by positron emission tomography (PET) and quality of life were part of the… CONTINUE READING
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