Effectiveness of high‐dose riboflavin in migraine prophylaxis A randomized controlled trial

@article{Schoenen1998EffectivenessOH,
  title={Effectiveness of high‐dose riboflavin in migraine prophylaxis A randomized controlled trial},
  author={Jean Schoenen and Jean Jacquy and Marc E. P. Lenaerts},
  journal={Neurology},
  year={1998},
  volume={50},
  pages={466 - 470}
}
A deficit of mitochondrial energy metabolism may play a role in migraine pathogenesis. [...] Key Method We now compared riboflavin (400 mg) and placebo in 55 patients with migraine in a randomized trial of 3 months duration. Using an intention-to-treat analysis, riboflavin was superior to placebo in reducing attack frequency (p = 0.005) and headache days (p = 0.012). Regarding the latter, the proportion of patients who improved by at least 50%, i.e. "responders," was 15% for placebo and 59% for riboflavin (p…Expand

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High-dose riboflavin could be an effective, low-cost prophylactic treatment of migraine devoid of short-term side effects and a placebo-controlled trial of its efficacy seems worthwhile. Expand
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