Effectiveness of first-line treatment with recombinant interleukin-1 receptor antagonist in steroid-naive patients with new-onset systemic juvenile idiopathic arthritis: results of a prospective cohort study.

@article{Vastert2014EffectivenessOF,
  title={Effectiveness of first-line treatment with recombinant interleukin-1 receptor antagonist in steroid-naive patients with new-onset systemic juvenile idiopathic arthritis: results of a prospective cohort study.},
  author={Sebastiaan J. Vastert and W de Jager and Bo Jan Noordman and Dirk Holzinger and Wietse Kuis and Berent Prakken and Nico Martinus Wulffraat},
  journal={Arthritis & rheumatology},
  year={2014},
  volume={66 4},
  pages={1034-43}
}
OBJECTIVE To conduct a prospective cohort study using anakinra, a recombinant IL-1 receptor antagonist (IL-1Ra), as first-line therapy in patients with new-onset systemic juvenile idiopathic arthritis (JIA). METHODS Therapy with recombinant IL-1Ra (2 mg/kg) was initiated in 20 patients who fulfilled the International League of Associations for Rheumatology criteria for systemic JIA, before systemic steroid treatment was administered. Patients were monitored clinically and immunologically. The… CONTINUE READING
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