Effectiveness of electrolyzed oxidized water irrigation in a burn-wound infection model.

Abstract

OBJECTIVE The purpose of the study was to determine whether electrolyzed oxidized water (EOW) functions as a bactericide in burn injury with Pseudomonas aeruginosa infection in a rat burn-wound model. METHODS Anesthetized Sprague-Dawley rats (n = 31) were subjected to third-degree burns to 30% of total body surface area. Two days after injury, all rats were infected with P. aeruginosa using 1 mL of a suspension containing 1 x 10(8) colony-forming units. Rats were assigned to one of three groups: no irrigation (group I), irrigation with physiologic saline (group II), or irrigation with EOW (group III). Blood culture, endotoxin levels, and survival rates were determined. RESULTS Survival rate was significantly higher in group III than in groups I or II (p < 0.0001). Serum endotoxin levels on day 3 after infection in group III were significantly lower than the levels in group I (p < 0.01) and group II (p < 0.01). There were significant differences between the three groups in the culture of P. aeruginosa (p < 0.05). CONCLUSION Irrigation and disinfection with EOW may become useful in preventing burn-wound sepsis.

3 Figures and Tables

010203020072008200920102011201220132014201520162017
Citations per Year

74 Citations

Semantic Scholar estimates that this publication has 74 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Nakae2000EffectivenessOE, title={Effectiveness of electrolyzed oxidized water irrigation in a burn-wound infection model.}, author={Hajime Nakae and Hiroto Inaba}, journal={The Journal of trauma}, year={2000}, volume={49 3}, pages={511-4} }