Effectiveness of corticosteroid treatment in acute pharyngitis: a systematic review of the literature.

  title={Effectiveness of corticosteroid treatment in acute pharyngitis: a systematic review of the literature.},
  author={Andrew Wing and Cristina Villa‐Roel and Benson Yeh and Barnet Eskin and Jeanette Buckingham and Brian H. Rowe},
  journal={Academic emergency medicine : official journal of the Society for Academic Emergency Medicine},
  volume={17 5},
  • A. WingC. Villa‐Roel B. Rowe
  • Published 1 May 2010
  • Medicine
  • Academic emergency medicine : official journal of the Society for Academic Emergency Medicine
OBJECTIVES The objective was to examine the effectiveness of corticosteroid treatment for the relief of pain associated with acute pharyngitis potentially caused by group A beta-hemolytic Streptococcus (GABHS). METHODS This was a systematic review of the literature. Data sources used were electronic databases (Cochrane Library, MEDLINE, EMBASE, Biosis Previews, Scopus, and Web of Science), controlled trial registration websites, conference proceedings, study references, experts in the field… 

Corticosteroids as standalone or add-on treatment for sore throat.

Oral or intramuscular corticosteroids, in addition to antibiotics, increase the likelihood of both resolution and improvement of pain in participants with sore throat, although significant heterogeneity was present.

Dexamethasone as Adjuvant Treatment in Patients with Acute Severe Pharyngitis: A Descriptive Study at Welcare Hospital Emergency Unit, Dubai, United Arab Emirates

It is suggested that dexamethasone is safe and effective to use as adjuvant for management of pain associated with acute GABHS pharyngitis and almost all patients experienced significant pain relief by 36 and 48 hours.

Adverse Effects of Steroid Therapy in Children With Pharyngitis With Unsuspected Malignancy

If steroids are to be used in children with pharyngitis or adenitis, the following recommendations should be strongly considered: Careful history and physical examination should be obtained and presence of hepatosplenomegaly or lymphadenopathy outside the cervical region should raise suspicions regarding an underlying malignancy.

Are corticosteroids an effective treatment of sore throat?

Corticosteroids administered with antibiotics for acute pharyngitis decrease the time to onset of pain relief by approximately 6 hours compared with antibiotics alone.

Corticosteroids for sore throat: a clinical practice guideline

The infographic provides the recommendation together with an overview of the absolute benefits and harms of corticosteroids in the standard GRADE format and any evidence that has emerged since the publication of this article.

27 Pharyngitis

Common Questions About Streptococcal Pharyngitis.

Nonsteroidal anti-inflammatory drugs are more effective than acetaminophen and placebo for treatment of fever and pain associated with GABHS pharyngitis; medicated throat lozenges used every two hours are also effective.

The Efficacy of Systemic Corticosteroids in Treatment of Respiratory Tract Infections During Hajj 2012

There is a need to conduct more comprehensive studies on effect of combination therapy with corticosteroids and antibiotics as well as their short-term and long-term adverse effects on the immune system.

No evidence for the effectiveness of systemic corticosteroids in acute pharyngitis, community-acquired pneumonia and acute otitis media

Overall, the data showed that there is, currently, no indication for the universal use of systemic corticosteroids in any of the reviewed diseases and, further, high-quality studies of all of these respiratory tract infections are needed in order to identify the patients for whom the prescription of cortICosteroids is rationally acceptable.



Corticosteroids for pain relief in sore throat: systematic review and meta-analysis

Corticosteroids provide symptomatic relief of pain in sore throat, in addition to antibiotic therapy, mainly in participants with severe or exudative sore throat.

Effectiveness of oral dexamethasone in the treatment of moderate to severe pharyngitis in children.

Children with moderate to severe pharyngitis had earlier onset of pain relief and shorter duration of sore throat when given oral dexamethasone, according to a randomized, double-blind, placebo-controlled clinical trial.

The role of betamethasone in the treatment of acute exudative pharyngitis.

Pain relief was greater and more rapid in patients treated with betamethasone as an adjuvant therapy in acute exudative pharyngitis.

A randomized clinical trial of oral versus intramuscular delivery of steroids in acute exudative pharyngitis.

The results of this clinical trial suggest that oral steroid and IM steroid provide similar levels of pain relief in acute exudative pharyngitis.

How effective are treatments other than antibiotics for acute sore throat?

Some non-antibiotic treatments may be more effective than antibiotics and should be investigated further with respect to efficacy, safety, and side-effects as potential firstline management options for acute sore throat.

A Pilot Study of 1 versus 3 Days of Dexamethasone as Add-On Therapy in Children With Streptococcal Pharyngitis

In this pilot study, children with GABHS pharyngitis who receive dexamethasone as add-on therapy have a more rapid improvement in general condition and level of activity and, for those receiving 3 daily doses of dexamETHasone, in resolution of throat pain.

Use of corticosteroids in treating infectious diseases.

It is concluded that corticosteroids are beneficial and safe for a wide variety of infections, although courses longer than 3 weeks should be withheld from patients with concomitant human immunodeficiency virus infection and low CD4 counts.

Incidence of acute rheumatic fever in the world: a systematic review of population-based studies

Despite an apparent fall in incidence over time, ARF incidence rates remain relatively high in non-Western countries, and studies with longitudinal data displayed a falling incidence rate over time.