Effectiveness of calretinin and role of age in the diagnosis of Hirschsprung disease

@article{Jorge2016EffectivenessOC,
  title={Effectiveness of calretinin and role of age in the diagnosis of Hirschsprung disease},
  author={Irene de Haro Jorge and Pedro Palaz{\'o}n Bellver and Victoria Julia Masip and Laura Saura Garc{\'i}a and Teresa Ribalta Farres and Daniel Cuadras Pallej{\`a} and Xavier Tarrado Castellarnau},
  journal={Pediatric Surgery International},
  year={2016},
  volume={32},
  pages={723-727}
}
ObjectiveGold standard in Hirschsprung disease (HD) diagnosis is rectal suction biopsy (RSB) with hematoxylin and eosin and acetylcholinesterase (ACE) stainings. Sensitivity is 83–93 % and specificity is between 95 and 99 %. The rate of non-conclusive results (NC) due to inadequate samples or variability in the interpretation is about 11–37.8 %. Interpretation is still difficult in neonates. Calretinin (C) is a calcium-binding protein, expressed in the nervous system. It has been introduced as… CONTINUE READING