Effectiveness of atypical antipsychotic drugs in patients with Alzheimer's disease.

@article{Schneider2006EffectivenessOA,
  title={Effectiveness of atypical antipsychotic drugs in patients with Alzheimer's disease.},
  author={L. S. Schneider and Pierre N. Tariot and Karen Stevens Dagerman and Sonia M. Davis and John K. Hsiao and Mohd Mansor Ismail and Barry D. Lebowitz and C. G. Lyketsos and J Michael Ryan and T. Scott Stroup and David L. Sultzer and Daniel A Weintraub and Jeffrey A. Lieberman},
  journal={The New England journal of medicine},
  year={2006},
  volume={355 15},
  pages={
          1525-38
        }
}
BACKGROUND Second-generation (atypical) antipsychotic drugs are widely used to treat psychosis, aggression, and agitation in patients with Alzheimer's disease, but their benefits are uncertain and concerns about safety have emerged. We assessed the effectiveness of atypical antipsychotic drugs in outpatients with Alzheimer's disease. METHODS In this 42-site, double-blind, placebo-controlled trial, 421 outpatients with Alzheimer's disease and psychosis, aggression, or agitation were randomly… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 28 references

Efficacy and adverse effects of atypical antipsychotics for dementia: meta-analysis of randomized, placebo-controlled trials.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry • 2006

. 9 . 10 . 11 . 12 . 13 . drug treatment for dementia : meta - analysis of randomized placebo - controlled tri

JA Racoosin
JAMA • 2005

Olanzapine (Zyprexa): increased incidence of cerebrovascular events in dementia trials

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne • 2004

Provisional diagnostic criteria for depression of Alzheimer disease: rationale and background.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry • 2002

Risperidone (Risperdal): increased rate of cerebrovascular events in dementia trials

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne • 2002