Effectiveness of antiretroviral therapy in HIV-infected children under 2 years of age.

  title={Effectiveness of antiretroviral therapy in HIV-infected children under 2 years of age.},
  author={Martina Penazzato and Andrew J. Prendergast and Jayne Tierney and M F Cotton and Diana M Gibb},
  journal={The Cochrane database of systematic reviews},
BACKGROUND In the absence of antiretroviral therapy (ART), over 50% of HIV-infected infants progress to AIDS and death by 2 years of age. However, there are challenges to initiate ART in early life, including the possibility of drug resistance in the context of prevention of mother-to-child transmission (PMTCT) programs, a paucity of drug choices , uncertain dosing for some medications and long-term toxicities. Key management decisions include when to start ART, what regimen to start, and… CONTINUE READING
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