Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.

@article{Lieberman2005EffectivenessOA,
  title={Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.},
  author={Jeffrey A. Lieberman and T. Scott Stroup and Joseph P. McEvoy and Marvin S. Swartz and Robert A. Rosenheck and Diana O. Perkins and Richard S. E. Keefe and Sonia M. Davis and Clarence E. Davis and Barry Lebowitz and Joanne B. Severe and John K. Hsiao},
  journal={The New England journal of medicine},
  year={2005},
  volume={353 12},
  pages={
          1209-23
        }
}
BACKGROUND The relative effectiveness of second-generation (atypical) antipsychotic drugs as compared with that of older agents has been incompletely addressed, though newer agents are currently used far more commonly. [] Key MethodRESULTS Overall, 74 percent of patients discontinued the study medication before 18 months (1061 of the 1432 patients who received at least one dose): 64 percent of those assigned to olanzapine, 75 percent of those assigned to perphenazine, 82 percent of those assigned to…

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References

SHOWING 1-10 OF 40 REFERENCES
Effectiveness and cost of olanzapine and haloperidol in the treatment of schizophrenia: a randomized controlled trial.
TLDR
Olanzapine does not demonstrate advantages compared with haloperidol (in combination with prophylactic benztropine) in compliance, symptoms, extrapyramidal symptoms, or overall quality of life, and its benefits in reducing akathisia and improving cognition must be balanced with the problems of weight gain and higher cost.
Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs
TLDR
A brief review and critique of the current therapeutic armamentarium for treating schizophrenia and drug development strategies and theories of mechanisms of action of antipsychotic drugs is provided, and focuses on novel targets for therapeutic agents for future drug development.
Dose Response and Dose Equivalence of Antipsychotics
TLDR
Evidence from randomized, placebo-controlled studies of patients with schizophrenia or schizoaffective disorder, which compared 2 or more doses of an antipsychotic to calculate the dose-response curve is reviewed to find 3.3 to 10 mg haloperidol to be the near-maximal ED range.
A comparison of risperidone and haloperidol for the prevention of relapse in patients with schizophrenia.
TLDR
Adult outpatients with clinically stable schizophrenia or schizoaffective disorder have a lower risk of relapse if they are treated with risperidone than if they were treated with haloperidol.
Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine.
TLDR
In this relatively brief study, the apparently increased comparative risk of agranulocytosis requires that the use of clozapine be limited to selected treatment-resistant patients.
A Meta-analysis of the Efficacy of Second-Generation Antipsychotics
TLDR
Some SGAs are more efficacious than FGAs, and, therefore,SGAs are not a homogeneous group, as suggested by consensus panel recommendations.
Effectiveness of second-generation antipsychotics in patients with treatment-resistant schizophrenia: a review and meta-analysis of randomized trials.
TLDR
It is confirmed that treatment-resistant schizophrenic patients have more favorable outcomes when treated with clozapine rather than a typical antipsychotic, as reflected by Brief Psychiatric Rating Scale total score, categorical response rate, Scale for the Assessment of Negative Symptoms score, Simpson-Angus Rating Scale score, and compliance rate.
An assessment of the independent effects of olanzapine and risperidone exposure on the risk of hyperlipidemia in schizophrenic patients.
TLDR
A strong association between olanZapine exposure and hyperlipidemia in schizophrenic patients is observed and the possible metabolic consequences of olanzapine use should be given serious consideration by treating physicians.
...
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3
4
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