Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.

@article{Lieberman2005EffectivenessOA,
  title={Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.},
  author={Jeffrey A. Lieberman and T. Scott Stroup and J P Mcevoy and Marvin S. Swartz and Robert A. Rosenheck and Diana O. Perkins and Richard S. E. Keefe and Stephen M. Davis and Clarence E. Davis and Barry D. Lebowitz and Joanne B. Severe and John K. Hsiao},
  journal={The New England journal of medicine},
  year={2005},
  volume={353 12},
  pages={
          1209-23
        }
}
BACKGROUND The relative effectiveness of second-generation (atypical) antipsychotic drugs as compared with that of older agents has been incompletely addressed, though newer agents are currently used far more commonly. We compared a first-generation antipsychotic, perphenazine, with several newer drugs in a double-blind study. METHODS A total of 1493 patients with schizophrenia were recruited at 57 U.S. sites and randomly assigned to receive olanzapine (7.5 to 30 mg per day), perphenazine (8… CONTINUE READING

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