Effectiveness of an Inactivated SARS-CoV-2 Vaccine in Chile

@article{Jara2021EffectivenessOA,
  title={Effectiveness of an Inactivated SARS-CoV-2 Vaccine in Chile},
  author={Alejandro Jara and Eduardo A. Undurraga and Cecilia Gonz{\'a}lez and Fabio Paredes and Tom{\'a}s Fontecilla and Gonzalo Jara and Alejandra Pizarro and Johanna Acevedo and Katherine Leo and Francisco Leon and Carlos Sans and Paulina Leighton and Pamela Su{\'a}rez and Heriberto E. Garc{\'i}a-Escorza and Rafael Araos},
  journal={The New England Journal of Medicine},
  year={2021}
}
Abstract Background Mass vaccination campaigns to prevent coronavirus disease 2019 (Covid-19) are occurring in many countries; estimates of vaccine effectiveness are urgently needed to support decision making. A countrywide mass vaccination campaign with the use of an inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine (CoronaVac) was conducted in Chile starting on February 2, 2021. Methods We used a prospective national cohort, including participants 16 years of… 

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References

SHOWING 1-10 OF 42 REFERENCES

BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting

This study in a nationwide mass vaccination setting suggests that the BNT162b2 mRNA vaccine is effective for a wide range of Covid-19–related outcomes, a finding consistent with that of the randomized trial.

Development of an inactivated vaccine candidate for SARS-CoV-2

Preclinical results of an early vaccine candidate called PiCoVacc, which protected rhesus macaque monkeys against SARS-CoV-2 infection when analyzed in short-term studies, support the clinical development and testing of Pi coVacc for use in humans.

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

The mRNA-1273 vaccine showed 94.1% efficacy at preventing Covid-19 illness, including severe disease, and Aside from transient local and systemic reactions, no safety concerns were identified.

Effectiveness of CoronaVac in the setting of high SARS-CoV-2 P.1 variant transmission in Brazil: A test-negative case-control study

Administration of at least one dose of CoronaVac showed effectiveness against symptomatic SARS-CoV-2 infection in the setting of epidemic P.1 transmission, underscoring the need to increase vaccination efforts in response to the spread of this variant in Brazil and globally.

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

A two-dose regimen of BNT162b2 conferred 95% protection against Covid-19 in persons 16 years of age or older and safety over a median of 2 months was similar to that of other viral vaccines.

Effectiveness of First Dose of COVID-19 Vaccines Against Hospital Admissions in Scotland: National Prospective Cohort Study of 5.4 Million People

A single dose of the BNT162b2 mRNA and ChAdOx1 vaccines resulted in substantial reductions in the risk of COVID-19 related hospitalisation in Scotland.