Effectiveness of amodiaquine, sulfadoxine-pyrimethamine, and combinations of these drugs for treating chloroquine-resistant falciparum malaria in Hainan Island, China.

@article{Huang1988EffectivenessOA,
  title={Effectiveness of amodiaquine, sulfadoxine-pyrimethamine, and combinations of these drugs for treating chloroquine-resistant falciparum malaria in Hainan Island, China.},
  author={Ou-lin Huang and Wei Ouyang and Jeff X Zhou and Zhong-xing Wu and Kam Y Z Zhang and J. K. Huang and X Z Cai and Xiuqin Pang and Shan-ming Fu and Xiaofei F Wang},
  journal={Bulletin of the World Health Organization},
  year={1988},
  volume={66 3},
  pages={353-8}
}
The study was carried out in 1985-86 in Hainan Island where Plasmodium falciparum is resistant to chloroquine. Fifty cases of falciparum malaria were treated with 1800 mg amodiaquine for 3 days: the cure rate was 65.3%, and the mean time to clear fever and asexual parasitaemia was 30.7 and 60.3 hours, respectively; 34.7% of cases showed RI or RII recrudescence, and one patient's temperature did not come down to normal within 7 days.Twenty-one cases were treated with sulfadoxine-pyrimethamine… CONTINUE READING