Effectiveness of adjunctive antidepressant treatment for bipolar depression.

@article{Sachs2007EffectivenessOA,
  title={Effectiveness of adjunctive antidepressant treatment for bipolar depression.},
  author={Gary S. Sachs and Andrew A. Nierenberg and Joseph R. Calabrese and Lauren B. Marangell and Stephen R. Wisniewski and L{\'a}szl{\'o} Gyulai and Edward S. Friedman and Charles L. Bowden and Mark D. Fossey and Michael Joshua Ostacher and Terence A. Ketter and Jayendra K. Patel and P{\'e}ter Hauser and Daniel J. Rapport and James Michael Martinez and Michael H. Allen and David J. Miklowitz and Michael W. Otto and Ellen B. Dennehy and Michael E. Thase},
  journal={The New England journal of medicine},
  year={2007},
  volume={356 17},
  pages={
          1711-22
        }
}
BACKGROUND Episodes of depression are the most frequent cause of disability among patients with bipolar disorder. The effectiveness and safety of standard antidepressant agents for depressive episodes associated with bipolar disorder (bipolar depression) have not been well studied. Our study was designed to determine whether adjunctive antidepressant therapy reduces symptoms of bipolar depression without increasing the risk of mania. METHODS In this double-blind, placebo-controlled study, we… 

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