Effectiveness of Temazepam with Short‐, Intermediate‐, and Long‐Term Use: Sleep Laboratory Evaluation

@article{Bixler1978EffectivenessOT,
  title={Effectiveness of Temazepam with Short‐, Intermediate‐, and Long‐Term Use: Sleep Laboratory Evaluation},
  author={Edward O. Bixler and Anthony Kales and Constantin R. Soldatos and Martin B. Scharf and Joyce D. Kales},
  journal={The Journal of Clinical Pharmacology},
  year={1978},
  volume={18}
}
The effectiveness of 30 mg temazepam (SaH 47-603) for inducing and maintaining sleep was evaluated in the sleep laboratory in six insomniac subjects under conditions of short-, intermediate-, and long-term drug administration. Administration of temazepam had no effect on sleep induction. In addition, effectiveness was not demonstrated for sleep maintenance: wake time after sleep onset was not significantly decreased on any of the three drug conditions, while the number of nightly awakenings was… Expand
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References

SHOWING 1-10 OF 13 REFERENCES
Hypnotic Efficacy of Triazolam: Sleep Laboratory Evaluation of Intermediate‐Term Effectiveness
TLDR
The data indicate that triazolam is effective for short-term use, loses most of its effectiveness with intermediate- term use, and its withdrawal is followed by a significant sorsening of sleep. Expand
Effectiveness of hypnotic drugs with prolonged use: Flurazepam and pentobarbital
TLDR
Pentobarbital was found to be effective in inducing and maintaining sleep only with short‐term drug administration, which strongly suggests that it is of limited value for insomniac patients who require nightly medication beyond short-term use. Expand
Readaptation to the sleep laboratory in insomniac subjects.
TLDR
A readaptation effect to the sleep laboratory was demonstrated for insomniac subjects who returned lo the laboratory for a second series of consecutive nights after spending one week at home, i.e. number of REM periods, min stage 4, and percentage stage 4 were decreased on the first night upon returning to the laboratory as compared to subsequent nights. Expand
Flunitrazepam, an Investigational Hypnotic Drug: Sleep Laboratory Evaluations
It is an analogue of nitrazepam (Mogadon*+), a hypnotic drug which has been widely used in Europe since 1965 but not available for clinical use in the United States. In a preliminary study of theExpand
Multiple Comparisons among Means
Abstract Methods for constructing simultaneous confidence intervals for all possible linear contrasts among several means of normally distributed variables have been given by Scheffe and Tukey. InExpand
Flunitrazepam, an investigational hypnotic drug: sleep laboratory investigations
  • J. Clin. Pharmacol. 17: 569
  • 1977
Long-term effectiveness of temazepam 30 mg h.s. on chronic insomniacs
  • Sleep Research
  • 1975
Methodology of sleep laboratory drug evaluations
  • In Hypnotics: Methods of Development and Evaluation,
  • 1975
Benzodiazepines and human sleep
  • In The Benzodiazepines,
  • 1973
Sleep laboratory and clinical studies of the effects of benzodiazepines on sleep: flurazepam, diazepam, chlordiazepoxide, and RO 5-4200
  • In The Benzodiazepines,
  • 1973
...
1
2
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