Effectiveness of Temazepam with Short‐, Intermediate‐, and Long‐Term Use: Sleep Laboratory Evaluation

  title={Effectiveness of Temazepam with Short‐, Intermediate‐, and Long‐Term Use: Sleep Laboratory Evaluation},
  author={Edward O. Bixler and Anthony Kales and Constantin R. Soldatos and Martin B. Scharf and Joyce D. Kales},
  journal={The Journal of Clinical Pharmacology},
  • E. Bixler, A. Kales, J. Kales
  • Published 3 February 1978
  • Medicine, Biology, Psychology
  • The Journal of Clinical Pharmacology
The effectiveness of 30 mg temazepam (SaH 47-603) for inducing and maintaining sleep was evaluated in the sleep laboratory in six insomniac subjects under conditions of short-, intermediate-, and long-term drug administration. Administration of temazepam had no effect on sleep induction. In addition, effectiveness was not demonstrated for sleep maintenance: wake time after sleep onset was not significantly decreased on any of the three drug conditions, while the number of nightly awakenings was… 
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