Effectiveness of PSD95 inhibitors in permanent and transient focal ischemia in the rat.

  title={Effectiveness of PSD95 inhibitors in permanent and transient focal ischemia in the rat.},
  author={Hong-Shuo Sun and Tracy Ann Doucette and Yitao Liu and Y Fang and Lucy M Teves and M. Aarts and Catherine L. Ryan and Paul B Bernard and Anthony Lau and Joan P Forder and Michael W. Salter and Yu Tian Wang and R Andrew Tasker and M Tymianski},
  volume={39 9},
BACKGROUND AND PURPOSE Postsynaptic density-95 inhibitors reduce ischemic brain damage without inhibiting excitatory neurotransmission, circumventing the negative consequences of glutamatergic inhibition. However, their efficacy in permanent ischemia and in providing permanent neuroprotection and neurobehavioral improvement in a practical therapeutic window is unproven. These were tested here under conditions that included fever, which is a common occurrence in clinical stroke. METHODS Six… CONTINUE READING
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