Effectiveness of Donor Natural Killer Cell Alloreactivity in Mismatched Hematopoietic Transplants

@article{Ruggeri2002EffectivenessOD,
  title={Effectiveness of Donor Natural Killer Cell Alloreactivity in Mismatched Hematopoietic Transplants},
  author={Loredana Ruggeri and Marusca Capanni and Elena Urbani and Katia Perruccio and Warren D. Shlomchik and Antonella Tosti and Sabrina Posati and Daniela Rogaia and Francesco Frassoni and Franco Aversa and Massimo Fabrizio Martelli and Andr{\'e}a Velardi},
  journal={Science},
  year={2002},
  volume={295},
  pages={2097 - 2100}
}
T cells that accompany allogeneic hematopoietic grafts for treating leukemia enhance engraftment and mediate the graft-versus-leukemia effect. Unfortunately, alloreactive T cells also cause graft-versus-host disease (GVHD). T cell depletion prevents GVHD but increases the risk of graft rejection and leukemic relapse. In human transplants, we show that donor-versus-recipient natural killer (NK)–cell alloreactivity could eliminate leukemia relapse and graft rejection and protect patients against… 
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3,190 Citations

Alloreactive natural killer cells in hematopoietic stem cell transplantation.

Innate immunity against hematological malignancies.

NK-cell alloreactivity may provide a novel, powerful tool for enhancing the efficacy and safety of allogeneic hematopoietic transplantation.

How important is NK alloreactivity and KIR in allogeneic transplantation?

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  • Biology, Medicine
    Best practice & research. Clinical haematology
  • 2016

The graft versus leukemia response after allogeneic hematopoietic stem cell transplantation.

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The factors influencing GVHD, ways to exploit rapid advances in knowledge of histocompatibility, chimerism and tolerance for fostering GVL over GV HD, and the use of cellular therapies including donor lymphocyte infusions for disease control are summarized.

Immune Reconstitution and Graft-Versus-Host Reactions in Rat Models of Allogeneic Hematopoietic Cell Transplantation

The rat as an experimental model of HCT between allogeneic individuals is discussed, the findings on lymphocyte reconstitution in transplanted rats are summarized, and the rat skin explant assay is introduced, a feasible alternative to in vivo transplantation studies.

Alloantigen expression on non-hematopoietic cells reduces graft-versus-leukemia effects in mice.

It is shown, in mouse models of MHC-matched, minor histocompatibility antigen-mismatched bone marrow transplantation, that alloantigen expression on host epithelium drives donor T cells into apoptosis and dysfunction during GVHD, resulting in a loss of GVL activity.

Adoptive Immunotherapy for Acute Myeloid Leukemia: From Allogeneic Hematopoietic Cell Transplantation to CAR T Cells

Novel adoptive immunotherapy strategies have been developed to generate immune response against the leukemic cells, while sparing GVHD.

Hematopoietic stem cell transplantation from full-haplotype mismatched donors.

  • F. Aversa
  • Medicine, Biology
    Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis
  • 2002

Immunobiology of allogeneic hematopoietic stem cell transplantation.

Current understanding of some of the issues that affect the success of allogeneic HSCT are reviewed, including host-versus-graft (HVG) reactions, graft-versu-host disease (GVHD), graft-Versus-tumor (GVT) activity, and restoration of functional immunity to prevent transplant-related opportunistic infections.
...

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