Effectiveness of COVID-19 vaccines against variants of concern, Canada

@inproceedings{Nasreen2021EffectivenessOC,
  title={Effectiveness of COVID-19 vaccines against variants of concern, Canada},
  author={Sharifa Nasreen and Hannah Chung and Siyi He and Kevin Antoine Brown and Jonathan B. Gubbay and Sarah A. Buchan and Deshayne B. Fell and Peter C. Austin and Kevin L. Schwartz and Maria E. Sundaram and Andrew J. Calzavara and Branson Chen and Mina Tadrous and Kumanan Wilson and Sarah E. Wilson and Jeffrey C. Kwong},
  booktitle={medRxiv},
  year={2021}
}
Objectives: To estimate the effectiveness of BNT162b2 (Pfizer-BioNTech), mRNA-1273 (Moderna), and ChAdOx1 (AstraZeneca) vaccines against symptomatic SARS-CoV-2 infection and severe outcomes (COVID-19 hospitalization or death) caused by the Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1), and Delta (B.1.617.2) variants of concern (VOCs) during December 2020 to May 2021. Methods: We conducted a test-negative design study using linked population-wide vaccination, laboratory testing, and health… 
BNT162b2 and mRNA-1273 COVID-19 vaccine effectiveness against the Delta (B.1.617.2) variant in Qatar
TLDR
Both BNT162b2 and mRNA-1273 are highly effective in preventing Delta hospitalization and death, but less so in preventing infection, particularly for BNT 162b2.
Waning of BNT162b2 Vaccine Protection against SARS-CoV-2 Infection in Qatar
TLDR
BNT162b2-induced protection against infection appears to wane rapidly after its peak right after the second dose, but it persists at a robust level against hospitalization and death for at least six months following the seconddose.
Duration of protection of BNT162b2 and mRNA-1273 COVID-19 vaccines against symptomatic SARS-CoV-2 Omicron infection in Qatar
BACKGROUND: Qatar has been experiencing a large SARS-CoV-2 Omicron (B.1.1.529) wave that started on December 19, 2021. We assessed duration of protection of BNT162b2 (Pfizer-BioNTech) and mRNA-1273
Rapid evaluation of COVID-19 vaccine effectiveness against VOC/VOIs by genetic mismatch
TLDR
Based on vaccine efficacy/effectiveness data of 11 vaccine products and 297,055 SARS-CoV-2 sequences collected in 20 regions, the relationship between genetic mismatch of circulating viruses against the vaccine strain and VE is analyzed.
BNT162b2 and mRNA-1273 COVID-19 vaccine effectiveness against the SARS-CoV-2 Delta variant in Qatar.
TLDR
Findings show robust effectiveness for both BNT162b2 and mRNA-1273 in preventing Delta hospitalization and death in Qatar's population, despite lower effectiveness in preventing infection, particularly for the BNT 162b2 vaccine.
Waning mRNA-1273 Vaccine Effectiveness against SARS-CoV-2 Infection in Qatar
TLDR
Protection against hospitalization and death appears robust with no evidence for waning for several months after the second dose of Moderna mRNA-1273, but protection against symptomatic infection was consistently higher than that against asymptomatic infection and waned more slowly.
Effectiveness of COVID-19 vaccines against SARS-CoV-2 variants of concern: a systematic review and meta-analysis
TLDR
Full vaccination of COVID-19 vaccines is highly effective against Alpha variant, and moderate effective against Beta, Gamma, and Delta variants, and booster vaccination is more effective against Delta and Omicron variants.
The effectiveness of BNT162b2 mRNA vaccine against COVID-19 caused by Delta variant of SARS-CoV-2: a systematic review and meta-analysis
TLDR
The BNT162b2 mRNA vaccine offers a substantial protection rate against RT-PCR confirmed COVID-19 caused by the Delta variant upon full vaccination, albeit with slightly reduced effectiveness relative to other strains of SARS-CoV-2.
Effectiveness of the ChAdOx1 vaccine in the elderly during SARS-CoV-2 Gamma variant transmission in Brazil
TLDR
Completion of the ChAdOx1 vaccine schedule afforded significantly increased protection over a single dose against mild and severe Covid-19 outcomes in elderly individuals during widespread Gamma variant transmission.
...
...

References

SHOWING 1-10 OF 21 REFERENCES
Effectiveness of COVID-19 vaccines against the B.1.617.2 variant
TLDR
After 2 doses of either vaccine there were only modest differences in vaccine effectiveness with the B.1.
mRNA-1273 COVID-19 vaccine effectiveness against the B.1.1.7 and B.1.351 variants and severe COVID-19 disease in Qatar.
TLDR
It is shown that vaccine effectiveness was negligible for 2 weeks after the first dose, but increased rapidly in the third and fourth weeks immediately before administration of a second dose, and against any COVID-19 hospitalization and death, even after a single dose.
Effectiveness of Covid-19 Vaccines against the B.1.617.2 (Delta) Variant
TLDR
Only modest differences in vaccine effectiveness were noted with the delta variant as compared with the alpha variant after the receipt of two vaccine doses, which would support efforts to maximize vaccine uptake with two doses among vulnerable populations.
Efficacy Estimates for Various COVID-19 Vaccines: What we Know from the Literature and Reports
TLDR
The efficacy against any disease with infection is 85% after a full course of vaccination for the COVID-19 vaccines, and the VE against severe disease, hospitalization or death averages close to 100%.
Single-dose mRNA vaccine effectiveness against SARS-CoV-2, including P.1 and B.1.1.7 variants: a test-negative design in adults 70 years and older in British Columbia, Canada
TLDR
A single dose of mRNA vaccine reduced the risk of SARS-CoV-2 in adults [≥]70-years-old by about two-thirds, with protection only minimally reduced against B.1.2.7 and P.11.1 variants.
Inflection in prevalence of SARS-CoV-2 infections missing the N501Y mutation as a marker of rapid Delta (B.1.617.2) lineage expansion in Ontario, Canada
TLDR
Delta is rapidly overtaking other SARS-CoV-2 variants in Ontario, and has a substantial transmission advantage, and an inflection in the proportion of cases missing the N501Y mutation from rapidly decreasing to rapidly increasing, may be an early warning signal for Delta lineage expansion.
Effectiveness of the BNT162b2 Covid-19 Vaccine against the B.1.1.7 and B.1.351 Variants
Effectiveness of COVID-19 vaccines against hospital admission with the Delta (B.1.617.2) variant
  • 2021
...
...