Effectiveness and toxicity of gentamicin in an experimental model of pyelonephritis: effect of the time of administration.


Temporal variations in the renal toxicity of aminoglycosides have been reported for experimental animals as well as for humans. In fact, maximal renal toxicity of aminoglycosides was observed when the drug was given during the rest period, while a lower toxicity was observed when the drug was injected during the activity period. The aim of the present study… (More)


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