Effectiveness and tolerability of electronic cigarette in real-life: a 24-month prospective observational study

  title={Effectiveness and tolerability of electronic cigarette in real-life: a 24-month prospective observational study},
  author={Riccardo Polosa and Jaymin B. Morjaria and Pasquale Caponnetto and D. Campagna and Cristina Russo and Angela Alamo and Maria Domenica Amaradio and Alfredo Fisichella},
  journal={Internal and Emergency Medicine},
Electronic cigarettes (e-Cigarette) are battery-operated devices designed to vaporise nicotine that may aid smokers to quit or reduce their cigarette consumption. Research on e-Cigarettes is urgently needed to ensure that the decisions of regulators, healthcare providers and consumers are evidence based. Here we assessed long-term effectiveness and tolerability of e-Cigarette used in a ‘naturalistic’ setting. This prospective observational study evaluated smoking reduction/abstinence in smokers… 

Cohort study of electronic cigarette use: effectiveness and safety at 24 months

E-cigarette use alone might support tobacco quitters remaining abstinent from smoking, but dual use did not improve the likelihood of quitting tobacco or e-cigarettes, but may be helpful to reduce tobacco consumption.

Electronic Cigarettes Efficacy and Safety at 12 Months: Cohort Study

If e-cigarette safety will be confirmed, however, the use of e-cigarettes alone may facilitate quitters remaining so, although e-smokers showed a minimal but significantly higher increase in self-rated health than other smokers.

Cohort study of electronic cigarette use: safety and effectiveness after 4 years of follow-up.

The complete switch to e-cig may help tobacco quitters remain abstinent, but e- cig use in addition to tobacco did not increase the likelihood of smoking cessation or reduction.

Effectiveness of the Electronic Cigarette: An Eight-Week Flemish Study with Six-Month Follow-up on Smoking Reduction, Craving and Experienced Benefits and Complaints

In a series of controlled lab sessions with e-cig naïve tobacco smokers, second generation e-cigs were shown to be immediately and highly effective in reducing abstinence induced cigarette craving and withdrawal symptoms, while not resulting in increases in eCO.

Nicotine delivery, tolerability and reduction of smoking urge in smokers following short-term use of one brand of electronic cigarettes

Blood plasma nicotine levels obtained from short-term use of e-cigarettes containing 1.6 % and 2.4 % nicotine were significant, but lower than those of conventional tobacco cigarettes, yet the reduction in craving symptoms were broadly comparable.

Duration of the effectiveness of nicotine electronic cigarettes on smoking cessation and reduction: Systematic review and meta-analysis

This meta-analysis shows the duration of the effectiveness of the nicotine electronic cigarette vs. non-nicotine electronic cigarette and NRT on smoking cessation and reduction and there are still uncertainties about the risks of its long-term use and its potential role as a gateway into smoking, particularly among young people.

Electronic Cigarettes in North America: History, Use, and Implications for Smoking Cessation

Background— Designed to mimic the look and feel of tobacco cigarettes, electronic cigarettes (e-cigarettes) may facilitate smoking cessation. However, the efficacy and safety of e-cigarette use for

The efficacy and short-term effects of electronic cigarettes as a method for smoking cessation: a systematic review and a meta-analysis

Limited low-quality evidence of a non-statistically significant trend toward smoking cessation in adults using nicotine e-cigarettes exists compared with other therapies or placebo, and is needed to inform policy decisions.



Effect of an electronic nicotine delivery device (e-Cigarette) on smoking reduction and cessation: a prospective 6-month pilot study

The use of e-Cigarette substantially decreased cigarette consumption without causing significant side effects in smokers not intending to quit, and perception and acceptance of the product was good.

Efficacy of the nicotine inhaler in smoking reduction: A double-blind, randomized trial.

The nicotine inhaler can help smokers who are unable or unwilling to quit to reduce daily cigarette consumption, which may be a health benefit on its own and may further promote quitting.

Effect of an electronic nicotine delivery device (e cigarette) on desire to smoke and withdrawal, user preferences and nicotine delivery: randomised cross-over trial

The 16 mg Ruyan V8 ENDD alleviated desire to smoke after overnight abstinence, was well tolerated and had a pharmacokinetic profile more like the Nicorette inhalator than a tobacco cigarette.

Smoking reduction with oral nicotine inhalers: double blind, randomised clinical trial of efficacy and safety

Nicotine inhalers effectively and safely achieved sustained reduction in smoking over 24 months and reduction with or without nicotine substitution may be a feasible first step towards smoking cessation in people not able or not willing to stop abruptly.

A Clinical Laboratory Model for Evaluating the Acute Effects of Electronic “Cigarettes”: Nicotine Delivery Profile and Cardiovascular and Subjective Effects

Under these acute testing conditions, neither of the electronic cigarettes exposed users to measurable levels of nicotine or CO, although both suppressed nicotine/tobacco abstinence symptom ratings and increased product acceptability ratings.

Electronic cigarettes: a survey of users

Ecigarettes were used mainly to quit smoking, and may be helpful for this purpose, but several respondents were concerned about potential toxicity.

Electronic cigarette: users profile, utilization, satisfaction and perceived efficacy.

E-cigarettes were used much as people would use nicotine replacement medications: by former smokers to avoid relapse or as an aid to cut down or quit smoking, and for quitting and relapse prevention.

Effect of a nicotine-free inhalator as part of a smoking-cessation programme

The results of the logistic model analysis indicate that a high GN-SBQ score is a strong independent predictor for successful quitting at 24 weeks in the PAIPO group, and nicotine-free inhalators may be beneficial when used in the context of smoking-cessation interventions.

Adolescent males' awareness of and willingness to try electronic cigarettes.