Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women.

@article{Karim2010EffectivenessAS,
  title={Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women.},
  author={Quarraisha Abdool Karim and Salim S Abdool Karim and Janet A. Frohlich and Anneke C. Grobler and Cheryl L. Baxter and Leila E Mansoor and Ayesha B. M. Kharsany and Sengeziwe Sibeko and Koleka P Mlisana and Zaheen Omar and Tanuja Narayansamy Gengiah and Silvia Maarschalk and Natasha Arulappan and Mukelisiwe Mlotshwa and Lynn Morris and Douglas Taylor},
  journal={Science},
  year={2010},
  volume={329 5996},
  pages={
          1168-74
        }
}
The Centre for the AIDS Program of Research in South Africa (CAPRISA) 004 trial assessed the effectiveness and safety of a 1% vaginal gel formulation of tenofovir, a nucleotide reverse transcriptase inhibitor, for the prevention of HIV acquisition in women. A double-blind, randomized controlled trial was conducted comparing tenofovir gel (n = 445 women) with placebo gel (n = 444 women) in sexually active, HIV-uninfected 18- to 40-year-old women in urban and rural KwaZulu-Natal, South Africa… CONTINUE READING
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