Effectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent patients with liver cirrhosis: randomised, double-blind controlled study

@article{Addolorato2007EffectivenessAS,
  title={Effectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent patients with liver cirrhosis: randomised, double-blind controlled study},
  author={Giovanni Addolorato and Lorenzo Leggio and Anna Ferrulli and Silvia Cardone and Giovanni Battista Gasbarrini},
  journal={The Lancet},
  year={2007},
  volume={370},
  pages={1915-1922}
}
BACKGROUND Intervention to achieve alcohol abstinence represents the most effective treatment for alcohol-dependent patients with liver cirrhosis; however, anticraving drugs might worsen liver disease. We aimed to investigate the effectiveness and safety of baclofen in achieving and maintaining alcohol abstinence in patients with liver cirrhosis. METHODS Between October, 2003, and November, 2006, 148 alcohol-dependent patients with liver cirrhosis were referred to the Institute of Internal… CONTINUE READING
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