Corpus ID: 28758176

Effectiveness and safety of Stevia rebaudiana dried leaves as an adjuvant in the short-term treatment of type 2 diabetes : A randomized , controlled , cross-over and double-blinded trial

  title={Effectiveness and safety of Stevia rebaudiana dried leaves as an adjuvant in the short-term treatment of type 2 diabetes : A randomized , controlled , cross-over and double-blinded trial},
  author={{\'A}ngela Pallar{\'e}s and Gen{\'i}s Carrasco and Youssef Nava and Oriol Pallar{\'e}s and I P{\'e}rez and Rosa Rif{\'a} and Miriam Aide Castillo Rodr{\'i}guez},
Article Type: Full Length Research Article Recent randomized controlled trials have demonstrated the utility of stevioside and related compounds, extracted and refined from stevia leaf plant, to improve blood glucose and blood pressure in patients with type 2 diabetes. However, up till date, no well-designed trials have shown that the dried leaves of the stevia plant have similar effects in medical use. A randomized, controlled, cross-over and double-blinded study was conducted to assess the… Expand

Figures and Tables from this paper

Safety and efficacy of health supplement (Stevia rebaudiana)
Although some countries still banned the use of stevia since lack of toxicology profile, it was credited with the various health benefits and was considered safe to be used as sugar substitution in patients with diabetes. Expand
Consumption of Non-nutritive Sweeteners: Cellular and Metabolic Effects
Background: The primary function of non-nutritive sweeteners is to provide the consumer with a sweet product without the caloric load of sugar. The consumption of non-nutritive sweeteners is relatedExpand


Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: a two-year, randomized, placebo-controlled study.
In this 2-year study in Chinese patients with mild hypertension, oral stevioside significantly decreased SBP and DBP compared with placebo, and QOL was improved, and no significant adverse effects were noted. Expand
Apparent lack of pharmacological effect of steviol glycosides used as sweeteners in humans. A pilot study of repeated exposures in some normotensive and hypotensive individuals and in Type 1 and Type 2 diabetics.
It is shown that oral steviol glycosides, taken as sweetener are well tolerated and have no pharmacological effect, except for the placebo Type 1 diabetics group where a significant difference was observed for systolic BP and glucose. Expand
Investigation of the antihypertensive effect of oral crude stevioside in patients with mild essential hypertension
The results suggest that oral crude stevioside is safe and supports the well‐established tolerability during long term use as a sweetener in Brazil and suggests that oral stevoside up to 15.0 mg/kg/day did not show an antihypertensive effect. Expand
Mechanism of the Antihypertensive Effect of Stevioside in Anesthetized Dogs
It is confirmed that stevioside is an effective antihypertensive natural product, and its hypotensive mechanism may be probably due to inhibition of the Ca2+ influx. Expand
Metabolism of Stevioside by Healthy Subjects
Oral stevioside is not directly effective as a hypotensive or hypoglycemic agent in healthy subjects at the dose administered in this study. Expand
Green tea extract reduces blood pressure, inflammatory biomarkers, and oxidative stress and improves parameters associated with insulin resistance in obese, hypertensive patients.
Daily supplementation with 379 mg of GTE favorably influences blood pressure, insulin resistance, inflammation and oxidative stress, and lipid profile in patients with obesity-related hypertension. Expand
Comparative effects of Stevia rebaudiana leaves and stevioside on glycaemia and hepatic gluconeogenesis.
Results showed that the reduction of glycaemia promoted by the treatment with SRB leaves was mediated, at least in part, by an inhibition of hepatic gluconeogenesis, but this effect did not involve stevioside and the activation of PPARgamma receptors. Expand
Mechanism of the hypoglycemic effect of stevioside, a glycoside of Stevia rebaudiana.
Stevioside was able to regulate blood glucose levels by enhancing not only insulin secretion, but also insulin utilization in insulin-deficient rats; the latter was due to decreased PEPCK gene expression in rat liver by stevioside's action of slowing down gluconeogenesis. Expand
The effect of stevioside on blood pressure and plasma catecholamines in spontaneously hypertensive rats.
The present data show that stevioside given intravenously to conscious SHR was effective in blood pressure reduction and there was no change in serum catecholamines in anaesthetized animals with this natural compound. Expand
Effect of Stevia rebaudiana on glucose tolerance in normal adult humans.
The extract of Stevia rebaudiana increased glucose tolerance and significantly decreased plasma glucose levels during the test and after overnight fasting in all volunteers. Expand