Effectiveness and safety of Saccharomyces boulardii for acute infectious diarrhea

  title={Effectiveness and safety of Saccharomyces boulardii for acute infectious diarrhea},
  author={Ener Cagri Dinleyici and Makbule Eren and Metehan Ozen and Zeynel Abidin Yargic and Yvan Vandenplas},
  journal={Expert Opinion on Biological Therapy},
  pages={395 - 410}
Introduction: Acute diarrhea continues to be a leading cause of morbidity, hospitalization and mortality worldwide and probiotics have been proposed as a complementary therapy in the treatment of acute diarrhea. Regarding the treatment of acute diarrhea, a few probiotics including Saccharomyces boulardii seem to be promising therapeutic agents. Areas covered: We performed a systematic review and meta-analysis regarding the use of S. boulardii in the treatment of acute infectious diarrhea with… 

Systematic review of probiotics for the treatment of community-acquired acute diarrhea in children

Probiotics may be efficacious in reducing diarrhea duration and stool frequency during a diarrhea episode and additional research is needed to understand the effect of probiotics as adjunct therapy for diarrhea among children in developing countries.

Comparative Study for Probiotics and Symbiotics Versus Placebo in Pediatrics Acute Diarrhea: Randomized Controlled Trial

Probiotics and symbiotics normalized stool consistency in pediatric diarrhea by day 4 and decreased the number of days with fever compared to control and the study did not show a statistically significant difference between the different probiotic and symbiotic treatment for the treatment of diarrhea.

Saccharomyces boulardii CNCM I-745 in different clinical conditions

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Introduction: In pediatrics, prebiotics and/or probiotics are added to infant formula, mainly to prevent diseases such as diarrheal disorders. Probiotic food supplements and medication are frequently

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Oral rehydration is the first choice for rehydrations in children with AGE and mild-to-moderate dehydration, and IV ondansetron administration to children with significant vomiting is an option, as its use is associated with lower hospital admission rates.

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Most interventions analyzed showed evidence of superiority to placebo in reducing the diarrhea, and no further role is suggested for studies comparing interventions against no treatment or placebo, or studies testing loperamide, MN, kaolin-pectin, vitamin A, prebiotics and diluted milk.

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Treatment with 5 × 1010 CFU of B. lactis B94 plus 900 mg inulin shortened the duration of acute watery diarrhea by an average of 31 h, and this decrease was most pronounced in cases of Rotavirus diarrhea.

The Role of Probiotics in Common Paediatric Gastrointestinal Diseases

According to current knowledge, two probiotic strains are recommended for antibiotic associated diarrhea prevention and treatment of acute gastroenteritis, LGG and S. boulardii.

Use of probiotics in pediatric infectious diseases

Current evidence and recommendations for the use of probiotics in childhood infectious diseases and recombinant probiotic strain represent a promising source of molecules for the development of novel anti-infectious therapy.



Treatment of Acute Diarrhea With Saccharomyces boulardii in Infants

The present study shows a reduction in diarrhea duration when S boulardii was given to children within 72 hours after the onset of acute diarrhea.

Efficacy and safety of Saccharomyces boulardii in amebiasis-associated diarrhea in children.

Addition of S. boulardii to antibiotic treatment of amebiasis-associated acute diarrhea in children does not seem to be more effective than metronidazole treatment alone, and the tolerance and side effects of the treatment regimens are similar.

Probiotics in infectious diarrhoea in children: are they indicated?

Infectious gastroenteritis continues to be a leading cause of mortality and morbidity worldwide. The cornerstone of treatment remains replacement of water and electrolyte losses with oral rehydration

Efficacy and Safety of Saccharomyces boulardii in Acute Childhood Diarrhea: A Double Blind Randomised Controlled Trial

There is initial evidence available that Saccharomyces boullardi may have a therapeutic role in the management of acute childhood diarrhea.

Saccharomyces boulardii for treating acute gastroenteritis in children: updated meta‐analysis of randomized controlled trials

This update of the meta-analysis of data from RCTs confirms that in otherwise healthy infants and children, the use of S. boulardii is associated with clinical benefits in the treatment of AGE, specifically a reduction in the duration of diarrhoea by approximately 1 day.

Probiotics for treating acute infectious diarrhoea

No difference was detected between probiotic and control groups for the risk of diarrhoea lasting ≥ 48 hours, and there were no clear differences in effect size for the primary outcomes in post hoc analyses according to decade of publication of studies and whether or not trials had been registered.

Saccharomyces boulardii in childhood

There is evidence that S. boulardii is beneficial for the treatment of acute gastroenteritis and the prevention of antibiotic-associated diarrhea and more data are needed in other indications such as traveller’s diarrhea, Helicobacter pylori eradication, and inflammatory bowel disease.

Clinical efficacy of Saccharomyces boulardii or metronidazole in symptomatic children with Blastocystis hominis infection

Metronidazole or S. boulardii has potential beneficial effects in B. hominis infection (symptoms, presence of parasites).

Current concepts in the evaluation, diagnosis and management of acute infectious diarrhea.

Effects of Saccharomyces boulardii in children with acute diarrhoea

The medians of the average stool frequency after the second day of the treatment were significantly lower in the S. boulardii group than in the placebo group, and the duration of diarrhoea was significantly reduced in the Hsieh group compared with theplacebo group.