Effectiveness and pharmacokinetics of indomethacin in premature newborns with patent ductus arteriosus

@article{Vert1980EffectivenessAP,
  title={Effectiveness and pharmacokinetics of indomethacin in premature newborns with patent ductus arteriosus},
  author={Paul Vert and Gabrio Bianchetti and Fr{\'e}d{\'e}ric Marchal and Pierre J P Monin and Paolo Lucio Morselli},
  journal={European Journal of Clinical Pharmacology},
  year={1980},
  volume={18},
  pages={83-88}
}
A review of the published data on pharmacological closure of PDA in premature newborns shows that doses of 0.2 mg/kg indomethacin are less successful when given enterally (18 to 85% closure) than when given intravenously (88 to 90% closure). The elimination half-life is markedly prolonged in premature newborns compared to adults but there are wide differences between the patients and some discrepancies between mean values reported by various authors. The present study compares clinical and… CONTINUE READING
10 Citations
22 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 22 references

Pharmacocindtique et effets pharmacodynamiques de l ' Indom 6 tacine chez le pr 6 matur 6

  • P Monin, C Dubruc, PL Morselli, MJ Boutroy, P Vert
  • 1980

Pharmacocindtique et effets pharmacodynamiques de l'Indom6tacine chez le pr6matur6. In: II6me Colloque de Pharmacologie pdrinatale, Narbonne 31 mai-ler juin 1979, INSERM, Paris in press

  • F Marchal, G Bianchetti, +4 authors P Vert
  • 1980

A double blind controlled study on the efficacy of indomethacin in closure of patent ductus arteriosus in premature infants

  • R Nestrud, D Hill, +5 authors R Readinger
  • Pediatr Res
  • 1979

Efficacy of indomethacin for symptomatic PDA: a double-blind control study

  • R Yanagi, K Aziz, CE Hunt
  • Pediatr Res
  • 1979

Intravenous indocin therapy in premature infants with PDA: a double-blind control study

  • TF Yeh, A Thalji, J Luken, D Raval, I Carr, RS Pilders
  • Pediatr Res
  • 1979

Similar Papers

Loading similar papers…