Effectiveness and cost of replacing a calcineurin inhibitor with sirolimus to slow the course of chronic kidney disease in renal allografts.

@article{Gonzlez2010EffectivenessAC,
  title={Effectiveness and cost of replacing a calcineurin inhibitor with sirolimus to slow the course of chronic kidney disease in renal allografts.},
  author={Fernando Gonz{\'a}lez and Miguel {\'A}ngel L{\'o}pez Espinoza and Enrique Reynolds and Patricia Garc{\'i}a Herrera and Oscar Antonio Prieto Espinoza and Ximena Rocca and Eduardo Lorca and Jos{\'e} Orestes Maga{\~n}a Hidalgo and Eric Roessler},
  journal={Transplantation proceedings},
  year={2010},
  volume={42 1},
  pages={
          284-7
        }
}
Renal grafts suffer a progressive decrease in glomerular filtration rate (GFR) because of several factors including calcineurin inhibitor (CNI) nephrotoxicity. Switching CNIs to sirolimus may improve this adverse prognosis. We performed a prospective, open-label clinical trial among 18 kidney transplant patients with more than 12 months of evolution (range, 385-1826 days), showing progressive GFR decreases and biopsies with interstitial fibrosis and tubular atrophy (IFTA). Immunosuppressive… CONTINUE READING
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