Effectiveness and Safety of Warfarin in Dialysis Patients With Atrial Fibrillation

@article{Liu2015EffectivenessAS,
  title={Effectiveness and Safety of Warfarin in Dialysis Patients With Atrial Fibrillation},
  author={Gang Liu and Ming Long and Xun Hu and Chengheng Hu and Xin-xue Liao and Zhi-min Du and Yu-gang Dong},
  journal={Medicine},
  year={2015},
  volume={94}
}
AbstractIn routine practice, warfarin is widely used in dialysis patients with atrial fibrillation (AF) for stroke prevention though the ratio of risks to benefits remains unclear. Recent cohort studies investigating the association between warfarin use and the risks of stroke and bleeding in dialysis patients with AF present conflicting results.The objective of this study was to assess the effectiveness and safety of warfarin use in patients with AF undergoing dialysis.Three databases PubMed… 
Efficacy and safety of warfarin in dialysis patients with atrial fibrillation: a systematic review and meta-analysis
TLDR
Among dialysis patients with AF, warfarin therapy was not associated with mortality and stroke/thromboembolism, but significantly increased the risk of major bleeding, and more rigorous studies are essential to demonstrate the effect ofwarfarin for stroke prophylaxis in dialysis Patients with AF.
Warfarin Use in Hemodialysis Patients With Atrial Fibrillation: A Systematic Review of Stroke and Bleeding Outcomes
TLDR
It is demonstrated that for patients with AF who are on hemodialysis, warfarin was not associated with reduced outcomes of stroke but was rather associated with increased bleeding events.
Atrial Fibrillation in Dialysis Patients: Time to Abandon Warfarin?
TLDR
The trade-offs implicated in warfarin use for this population, the promises of newly developed drugs, the role of dialysis as atrial fibrillation trigger, as well as potential non-pharmacological management options suitable in selected clinical situations are discussed.
Ef fi cacy and safety of warfarin in dialysis patients with atrial fi brillation : a systematic review and meta-analysis
TLDR
Among dialysis patients with AF, warfarin therapy was not associated with mortality and stroke/thromboembolism, but significantly increased the risk of major bleeding, and more rigorous studies are essential to demonstrate the effect of warFarin for stroke prophylaxis in dialysis Patients with AF.
Treatment of atrial fibrillation with warfarin among older adults with end stage renal disease
TLDR
Despite the unclear benefit and increased bleeding risk of warfarin treatment in patients with ESRD, 1 in 8 older adults undergoing dialysis with incident AF in the US who had high risk of bleeding used warFarin.
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