Effective treatment of models of multiple sclerosis by matrix metalloproteinase inhibitors.

@article{Liedtke1998EffectiveTO,
  title={Effective treatment of models of multiple sclerosis by matrix metalloproteinase inhibitors.},
  author={Wolfgang B Liedtke and Barbara A Cannella and R J Mazzaccaro and John M. Clements and Karen M. Miller and Kai W Wucherpfennig and Andrew J. H. Gearing and Cedric S Raine},
  journal={Annals of neurology},
  year={1998},
  volume={44 1},
  pages={35-46}
}
The proinflammatory Th1 cytokine, tumor necrosis factor-alpha (TNF alpha), the cell death signaling molecule FasL, and several extracellular matrix degrading metalloproteinases have been implicated in the pathogenesis of multiple sclerosis (MS). The latter enzymes, as well as TNF alpha-converting enzyme and FasL-converting enzyme, can be blocked by matrix metalloproteinase inhibitors (MMPIs). In this study, we show that a potent MMPI was clinically effective in an animal model for MS… CONTINUE READING
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