Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3

  title={Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3},
  author={Nahid A Khan and Mari P Auranen and Ilse Paetau and Eija Pirinen and Liliya Euro and Saara Forsstr{\"o}m and Lotta Pasila and Vidya Velagapudi and Christopher J. Carroll and Johan Auwerx and Anu Suomalainen},
  booktitle={EMBO molecular medicine},
Nutrient availability is the major regulator of life and reproduction, and a complex cellular signaling network has evolved to adapt organisms to fasting. These sensor pathways monitor cellular energy metabolism, especially mitochondrial ATP production and NAD(+)/NADH ratio, as major signals for nutritional state. We hypothesized that these signals would be modified by mitochondrial respiratory chain disease, because of inefficient NADH utilization and ATP production. Oral administration of… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 13 times over the past 90 days. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 73 extracted citations


Publications referenced by this paper.
Showing 1-10 of 37 references

- non - autonomous nature of electron transport chain - mediated longevity

  • AP Gomes, NL Price, +7 authors BP Hubbard
  • 2013
1 Excerpt

Similar Papers

Loading similar papers…