Effective treatment of gut barrier dysfunction using an antioxidant, a PAF inhibitor, and monoclonal antibodies against the adhesion molecule PECAM-1.

@article{Sun2002EffectiveTO,
  title={Effective treatment of gut barrier dysfunction using an antioxidant, a PAF inhibitor, and monoclonal antibodies against the adhesion molecule PECAM-1.},
  author={Zhengwu Sun and Knut J Olanders and Ake Lasson and Marwan Dib and Martin Annborn and Klara M Andersson and Xiangdong Wang and Roland I Andersson},
  journal={The Journal of surgical research},
  year={2002},
  volume={105 2},
  pages={220-33}
}
BACKGROUND Oxygen free radicals (OFRs), platelet activating factor (PAF), cell adhesion molecules, and transmigration of polymorphonuclear leukocytes through the gut barrier are probably all essential in the development of gut barrier dysfunction following intestinal ischemia and reperfusion (I/R). Pretreatment and early treatment of I/R with the OFRs-scavenger (NAC), the PAF inhibitor lexipafant, and monoclonal antibodies against the adhesion molecule PECAM-1 (anti-PECAM-1-Mab) have been… CONTINUE READING

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