Effective treatment of edema and endothelial barrier dysfunction with imatinib.

@article{Aman2012EffectiveTO,
  title={Effective treatment of edema and endothelial barrier dysfunction with imatinib.},
  author={Jurjan Aman and Jan S M van Bezu and Amin Damanafshan and Stephan Huveneers and Etto C. Eringa and Steven M. Vogel and Arie Bastiaan Johan Groeneveld and Anton Vonk Noordegraaf and Victor W. M. van Hinsbergh and Geerten P. van Nieuw Amerongen},
  journal={Circulation},
  year={2012},
  volume={126 23},
  pages={2728-38}
}
BACKGROUND Tissue edema and endothelial barrier dysfunction as observed in sepsis and acute lung injury carry high morbidity and mortality, but currently lack specific therapy. In a recent case report, we described fast resolution of pulmonary edema on treatment with the tyrosine kinase inhibitor imatinib through an unknown mechanism. Here, we explored the effect of imatinib on endothelial barrier dysfunction and edema formation. METHODS AND RESULTS We evaluated the effect of imatinib on… CONTINUE READING
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