Effective treatment of chemoresistant breast cancer in vitro and in vivo by a factor VII-targeted photodynamic therapy

@inproceedings{Duanmu2011EffectiveTO,
  title={Effective treatment of chemoresistant breast cancer in vitro and in vivo by a factor VII-targeted photodynamic therapy},
  author={Jinzhong Duanmu and Jijun Cheng and Junqian Xu and Carmen J Booth and Zhiwei Hu},
  booktitle={British Journal of Cancer},
  year={2011}
}
Background:The purpose of this study was to test a novel, dual tumour vascular endothelial cell (VEC)- and tumour cell-targeting factor VII-targeted Sn(IV) chlorin e6 photodynamic therapy (fVII-tPDT) by targeting a receptor tissue factor (TF) as an alternative treatment for chemoresistant breast cancer using a multidrug resistant (MDR) breast cancer line MCF-7/MDR.Methods:The TF expression by the MCF-7/MDR breast cancer cells and tumour VECs in MCF-7/MDR tumours from mice was determined… CONTINUE READING

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