Effective treatment of Kimura’s disease with leflunomide in combination with glucocorticoids

@article{Dai2011EffectiveTO,
  title={Effective treatment of Kimura’s disease with leflunomide in combination with glucocorticoids},
  author={Lie Dai and Xiu-ning Wei and Dong-hui Zheng and Ying-Qian Mo and Frank Pessler and Bai-yu Zhang},
  journal={Clinical Rheumatology},
  year={2011},
  volume={30},
  pages={859-865}
}
Kimura’s disease (KD) is a rare, benign, chronic inflammatory disease which typically presents as persisting or recurring tumor-like lesions in the head and neck area that can be easily misdiagnosed. We report one patient with KD treated with leflunomide in combination with glucocorticoids and analyzed the literature on treatment of KD. The patient had a recurrent mass in the left upper arm with eosinophilia and elevated serum IgE but no renal involvement. The clinical manifestations improved… 

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The beneficial effect of cetirizine—a selective H1 receptor blocker—in a patient with Kimura’s disease is described.

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This case shows that in addition to previously reported associations, Kimura disease may be associated with eosinophilic panniculitis and that cyclosporine could be effective in its treatment.

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Results of immunohistochemical examination of platelet‐derived growth factor receptor‐α and c‐Kit in tissues from patients with KD suggested that Imatinib might be an effective drug for the treatment of the disease.

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