Effective therapy with anti-TNF-alpha in patients with psoriatic arthritis is associated with decreased levels of metalloproteinases and angiogenic cytokines in the sera and skin lesions.

@article{CordialiFei2007EffectiveTW,
  title={Effective therapy with anti-TNF-alpha in patients with psoriatic arthritis is associated with decreased levels of metalloproteinases and angiogenic cytokines in the sera and skin lesions.},
  author={Paola Cordiali-Fei and Elisabetta Trento and Giovanna D'agosto and Valentina Bordignon and Anna Mussi and Marco Ardig{\`o} and Antonio Mastroianni and Antonella Vento and Francesco Maria Solivetti and Enzo Berardesca and Fabrizio Ensoli},
  journal={Annals of the New York Academy of Sciences},
  year={2007},
  volume={1110},
  pages={578-89}
}
Tumor necrosis factor-alpha (TNF-alpha) plays a central role in sustaining the inflammatory process in the skin as well as in the joints of patients with psoriasis and psoriatic arthritis. In fact, biological therapies based on monoclonal antibodies against TNF-alpha have been proven to be effective on both the arthropathy and the cutaneous symptoms of the disease. Among the several effects produced by TNF-alpha on keratinocytes there is the induction of expression of MMP-9, a matrix… CONTINUE READING