Effective therapy of the LP-BM5 murine retrovirus-induced lymphoproliferative immunodeficiency disease with diethyldithiocarbamate.

@article{Hersh1991EffectiveTO,
  title={Effective therapy of the LP-BM5 murine retrovirus-induced lymphoproliferative immunodeficiency disease with diethyldithiocarbamate.},
  author={Evan M. Hersh and Carole Y. Funk and Kay L. Ryschon and Eskild A Petersen and Donald E. Mosier},
  journal={AIDS research and human retroviruses},
  year={1991},
  volume={7 6},
  pages={553-61}
}
The effects of therapy with the immunomodulator diethyldithiocarbamate (DTC) on the manifestation and natural history of LP-BM5 murine retrovirus infection in adult C57 Black 6 mice was investigated. DTC itself, had limited effects on the spleen weight, serum IgM, or mitogen responses of the non-virus-infected control mice when evaluated over a 9-week period. The virus inoculum administered was such that there was approximately a twofold increase in serum IgM and a halving of phytohemagglutinin… CONTINUE READING

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