Effective therapy of experimental human malignant melanomas with a targeted cytotoxic somatostatin analogue without induction of multi-drug resistance proteins.

@article{Keller2006EffectiveTO,
  title={Effective therapy of experimental human malignant melanomas with a targeted cytotoxic somatostatin analogue without induction of multi-drug resistance proteins.},
  author={Gunhild Keller and Andrew V Schally and Attila A. Nagy and Benjamin Eugene Baker and G Abor Halmos and J{\"o}rg Engel},
  journal={International journal of oncology},
  year={2006},
  volume={28 6},
  pages={
          1507-13
        }
}
Malignant melanomas are characterized by a high intrinsic resistance to chemotherapy. Multiple drug resistance (MDR) can be mediated by transport proteins such as MDR-1, multidrug resistance-associated protein (MRP) or lung resistance protein (LRP). The cytotoxic analogue of somatostatin AN-238 consisting of 2-pyrrolinodoxorubicin (AN-201) linked to a somatostatin analogue RC-121 binds to receptors for somatostatin and is targeted to tumors expressing these receptors. We evaluated the… CONTINUE READING

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