Effective ribavirin concentration in hamster brains for antiviral chemotherapy for subacute sclerosing panencephalitis.

@article{Ishii1996EffectiveRC,
  title={Effective ribavirin concentration in hamster brains for antiviral chemotherapy for subacute sclerosing panencephalitis.},
  author={Tsutomu Ishii and Moritoshi Hosoya and Shuichi Mori and Shibro Shigeta and Hitoshi Suzuki},
  journal={Antimicrobial agents and chemotherapy},
  year={1996},
  volume={40 1},
  pages={241-3}
}
The ribavirin concentration in hamster brains was measured by a high-performance liquid chromatography (HPLC) system and a bioassay system. When ribavirin was administered intracranially at a dosage of 10 mg/kg of body weight per day for 10 days, a dosage which results in 100% survival of hamsters infected with subacute sclerosing panencephalitis (SSPE) virus and which inhibits the replication of SSPE virus in hamster brains, the ribavirin concentration in the brains estimated by HPLC and… CONTINUE READING

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