Effective reduction of biofilm through photothermal therapy by gold core@shell based mesoporous silica nanoparticles

  title={Effective reduction of biofilm through photothermal therapy by gold core@shell based mesoporous silica nanoparticles},
  author={Ana Garc{\'i}a and Blanca Gonz{\'a}lez and Catherine Malinda Harvey and Isabel Izquierdo-Barba and Mar{\'i}a Vallet‐Reg{\'i}},
  journal={Microporous and Mesoporous Materials},

Figures and Tables from this paper

Superparamagnetic Iron Oxide Nanoparticles Decorated Mesoporous Silica Nanosystem for Combined Antibiofilm Therapy
The results of the present study show that combined hyperthermia and antibiotic treatment is a promising approach for the effective management of biofilm-associated infections.
Nanoantibiotics Based in Mesoporous Silica Nanoparticles: New Formulations for Bacterial Infection Treatment
This manuscript highlights the major scientific achievements accomplished by professor Vallet-Regí’s research group in the field of silica-based mesoporous materials for drug delivery and brings out her pivotal role on the envisage of a new era of nanoantibiotics by using a deep knowledge on mesoporus materials as drug delivery systems.
Bacteria-Assisted Transport of Nanomaterials to Improve Drug Delivery in Cancer Therapy
This review would summarize the literature on the anchoring methods of diverse nanosystems in bacteria and, interestingly, their advantages and possible applications in cancer therapy.
Effect of Gold Nanostars Plus Amikacin against Carbapenem-Resistant Klebsiella pneumoniae Biofilms
GNS in combination with amikacin represent a promising anti-CR-KP nanomaterial and measures the effect of GNS on cell proliferation and biocompatibility in invertebrate in vivo models.
Recent advances in nanotechnology for eradicating bacterial biofilm
The aim of this review is to present a complete vision of nanobiotechnology-based approaches for eradicating bacterial biofilms and fighting antimicrobial tolerance.


Impact of the antibiotic-cargo from MSNs on Gram-positive and Gram-negative bacterial biofilms.
Single Continuous Near-Infrared Laser-Triggered Photodynamic and Photothermal Ablation of Antibiotic-Resistant Bacteria Using Effective Targeted Copper Sulfide Nanoclusters.
This work took advantage of the excellent photothermal and photodynamic properties of copper sulfide nanoparticles upon NIR laser irradiation and thiazole derivative as a membrane-targeting cationic ligand toward bacteria to highlight the promise of the highly versatile multifunctional nanoantibiotics in bacterial infection.
Surface-Adaptive, Antimicrobially Loaded, Micellar Nanocarriers with Enhanced Penetration and Killing Efficiency in Staphylococcal Biofilms.
The preparation of surface-adaptive, Triclosan-loaded micellar nanocarriers showing enhanced biofilm penetration and accumulation, electrostatic targeting at acidic pH toward negatively charged bacterial cell surfaces in a biofilm, and antimicrobial release due to degradation of the micelle core by bacterial lipases constitutes a highly effective pathway to control blood-accessible staphylococcal biofilms using antimicrobials, bypassing biofilm recalcitrance to antimicrobial penetration.
Biofilm Inhibition and Elimination Regulated by Cationic Conjugated Polymers.
In this work, we demonstrate that water-soluble conjugated polymers (PFP) have the ability to inhibit biofilm formation and eradicate mature established biofilm using reactive oxygen species (ROS)
Eradicating group A streptococcus bacteria and biofilms using functionalised multi-wall carbon nanotubes
The premise that carbon nanotubes may be effectively utilised as highly localised photothermal agents with the potential for translation into the clinical treatment of bacterial infections of soft tissue is supported.
Nanomaterials with a photothermal effect for antibacterial activities: an overview.
Four functional categories of antibacterial nanomaterials with a photothermal conversion effect are classified: carbon-based nanoconjugates of graphene derivatives or carbon nanotubes, noble metal nanom material mainly from gold and silver, metallic compound nanocomposites, and polymeric as well as other nanostructures.
Targeted photothermal lysis of the pathogenic bacteria, Pseudomonas aeruginosa, with gold nanorods.
This work uses gold nanorods that have been covalently linked to primary antibodies to selectively destroy the pathogenic Gram-negative bacterium, Pseudomonas aeruginosa, and finds that, following nanorod attachment to the bacterial cell surface, exposure to near-infrared radiation results in a significant reduction in bacterial cell viability.