Effective protection by high efficiency bicistronic DNA vaccine against infectious bursal disease virus expressing VP2 protein and chicken IL-2.

@article{Kumar2009EffectivePB,
  title={Effective protection by high efficiency bicistronic DNA vaccine against infectious bursal disease virus expressing VP2 protein and chicken IL-2.},
  author={S. M. Dilip Kumar and Yadvinder S. Ahi and Shardul S. Salunkhe and Monika Koul and Ashok Tiwari and Praveen Kumar Gupta and Anant Rai},
  journal={Vaccine},
  year={2009},
  volume={27 6},
  pages={864-9}
}
Infectious bursal disease (IBD) is an acute and contagious viral infection of young chickens caused by IBD virus (IBDV). IBDV belongs to genus Avibirnavirus of family Birnaviridae. It is a non-enveloped virus with icosahedral symmetry that contains two segments of double-stranded RNA. The virus affects the lymphoid tissues of chickens, mainly the B cells of bursa of Fabricius, leading to severe and prolonged immunosuppression. VP2, a major structural protein of IBDV, contains antigenic epitopes… CONTINUE READING

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