Effective protection and controlled release of insulin by cationic beta-cyclodextrin polymers from alginate/chitosan nanoparticles.

@article{Zhang2010EffectivePA,
  title={Effective protection and controlled release of insulin by cationic beta-cyclodextrin polymers from alginate/chitosan nanoparticles.},
  author={Nan Zhang and Jiahui Li and Wenfeng Jiang and Chunhong Ren and Jianshu Li and Jianyu Xin and Ke Li},
  journal={International journal of pharmaceutics},
  year={2010},
  volume={393 1-2},
  pages={212-8}
}
In an alginate/chitosan nanoparticle system, insulin was protected by forming complexes with cationic beta-cyclodextrin polymers (CPbetaCDs), which were synthesized from beta-cyclodextrin (beta-CD), epichlorohydrin (EP) and choline chloride (CC) through a one-step polycondensation. Due to the electrostatic attraction between insulin and CPbetaCDs, as well as the assistance of its polymeric chains, CPbetaCDs could effectively protect insulin under simulated gastrointestinal conditions. The… CONTINUE READING

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