Effective photodynamic therapy of actinic keratoses on the head and face with a novel, self‐adhesive 5‐aminolaevulinic acid patch

@article{Hauschild2009EffectivePT,
  title={Effective photodynamic therapy of actinic keratoses on the head and face with a novel, self‐adhesive 5‐aminolaevulinic acid patch},
  author={Axel Hauschild and Georg Popp and E Stockfleth and K G Meyer and Dirk Imberger and Peter Mohr and G{\"o}tz Itschert and Roland Prof. Dr. Kaufmann and Karsten Neuber and Yvonne Frambach and Harald p. M. Gollnick and Marcus Brunnert and Marcus Stocker and Christoph Ortland and Sigrid Karrer},
  journal={Experimental Dermatology},
  year={2009},
  volume={18}
}
Background:  Photodynamic therapy (PDT) is increasingly used for the treatment of actinic keratosis (AK). 
Photodynamic therapy with a 5‐ALA patch does not increase the risk of conversion of actinic keratoses into squamous cell carcinoma
It is important to collect data about the risk of transformation of an actinic keratosis (AK) lesion into squamous cell carcinoma (SCC) after a single photodynamic therapy (PDT) with 5‐ALA patch for
Optimization of photodynamic therapy with a novel self‐adhesive 5‐aminolaevulinic acid patch: results of two randomized controlled phase III studies
TLDR
A thin self‐adhesive patch containing 5‐aminolaevulinic acid (5‐ALA) was developed to facilitate PDT and showed promising results in treatment of actinic keratoses.
Long‐term follow‐up of photodynamic therapy with a self‐adhesive 5‐aminolaevulinic acid patch: 12 months data
Background  Photodynamic therapy with a self‐adhesive 5‐aminolaevulinic acid (5‐ALA) patch shows high efficacy rates in the treatment of mild to moderate actinic keratosis (AK) in short term trials.
Photodynamic therapy with topical methyl‐ and hexylaminolevulinate for prophylaxis and treatment of UV‐induced SCC in hairless mice
TLDR
Photodynamic therapy with topical methyl‐ and hexylaminolevulinate for prophylaxis and treatment of UV‐induced SCC in hairless mice is described.
Adverse effects of topical photodynamic therapy
  • S. Ibbotson
  • Medicine
    Photodermatology, photoimmunology & photomedicine
  • 2011
TLDR
A review explores the adverse effects of topical PDT, particularly for the treatment of superficial non‐melanoma skin cancer and dysplasia.
Studies of MAL in PDT Using Different Light Sources to Treat Actinic Keratosis
TLDR
Several appropriately designed clinical trials with adequate sample sizes have looked at PDT alone or compared it to placebo or cryotherapy; their findings demonstrated response rates between 69% and 91% (Table 1), supporting the clinical application of this treatment in controversies in Dermatology.
5-Aminolaevulinic acid patch photodynamic therapy for the treatment of actinic keratoses: preliminary results from an Italian study in the real-life setting.
TLDR
The results confirm that 5-ALA patch PDT is a good option for AK treatment in clinical practice, it is easy to use, effective and well tolerated even in difficult-to-treat-areas and has an excellent cosmetic outcome.
Photodynamic therapy simplified: nonprepared, moderate‐grade actinic keratosis lesions respond equally well to 5‐aminolaevulinic acid patch photodynamic therapy as do mild lesions
TLDR
The results statistically confirm the superiority of 5-ALA patch PDT over placebo patch PDT (both confirmatory trials) and cryosurgery (clinical trial AK04) for both lesion grades.
Photodynamic therapy with 5‐aminolevulinate patch for the treatment of superficial basal cell carcinomas
TLDR
This study suggests that ALA patches for sBCCs have good efficacy rates and excellent safety profile and is an effective treatment indicated by food and drug administration and european medicines agency only for grade I to II actinic keratosis located on the scalp and face.
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References

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Levulan ® : the first approved topical photosensitizer for the treatment of actinic keratosis
  • E. Jeffes
  • Medicine
    The Journal of dermatological treatment
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TLDR
One Food and Drug Administration-approved treatment for AK of the face and scalp is photodynamic therapy with 20% aminolevulinic acid (ALA), and this advanced technology has been demonstrated in clinical trials to be effective and well tolerated by patients.
Intraindividual, right–left comparison of topical methyl aminolaevulinate‐photodynamic therapy and cryotherapy in subjects with actinic keratoses: a multicentre, randomized controlled study
TLDR
Treatment should not only be effective, but also well tolerated and allow for good cosmesis on typical sun‐exposed highly visible body sites.
Photodynamic Therapy in the Treatment of Actinic Keratosis †
TLDR
The efficacy and the low risk of side effects of PDT have resulted in a high patient preference in clinical trials and the value of PDT in comparison with cryotherapy or 5‐fluorouracil is discussed.
Photodynamic therapy with topical application of 5-aminolevulinic acid in the treatment of actinic keratoses: an initial clinical study.
TLDR
This study demonstrated the potential of good efficacy and tolerability in the treatment of AK using topical ALA-PDT and how efficacy for lesions on the hand can be improved and whether PDT is able to concur with established treatment modalities remains to be shown in further studies.
Photodynamic therapy with topical methyl aminolevulinate for actinic keratosis: results of a prospective randomized multicenter trial.
TLDR
In this small study, PDT using topical MAL was a safe and effective treatment for actinic keratoses with excellent cosmetic outcome and is a promising treatment that could benefit from further study.
Photodynamic therapy of actinic keratoses with topical aminolevulinic acid hydrochloride and fluorescent blue light.
TLDR
Topical ALA PDT using a nonlaser, blue light source is an effective treatment for multiple AKs and is completely cleared 8 weeks after a single photodynamic treatment.
Fluorescence characteristics and pharmacokinetic properties of a novel self-adhesive 5-ALA patch for photodynamic therapy of actinic keratoses
TLDR
PPIX-specific fluorescence in AK lesions can be steered by application duration of this novel 5-ALA patch, and clinical efficacy of the patch in PDT will be investigated in further clinical trials.
Split‐Face Comparison of Photodynamic Therapy with 5‐Aminolevulinic Acid and Intense Pulsed Light Versus Intense Pulsed Light Alone for Photodamage
TLDR
Short-contact ALA-PDT-IPL brings about greater improvement in photodamaged skin and greater clearance of AK lesions than IPL alone, further confirming the usefulness of ALA -PDT in photorejuvenation.
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