Effective open-label treatment of tourette's disorder with olanzapine.

  title={Effective open-label treatment of tourette's disorder with olanzapine.},
  author={Mara Stamenkovic and Shird Dieter Schindler and Harald Nikolaus Aschauer and Martina de Zwaan and Ulrike Willinger and E Resinger and Siegfried Kasper},
  journal={International clinical psychopharmacology},
  volume={15 1},
Olanzapine is an atypical antipsychotic drug which shows a high antagonistic affinity to the D1, D2 and D4 and the 5-HT2A and 5-HT2c receptors. The goal of our investigation was to assess the efficacy of olanzapine in patients with Tourette's disorder who were either antipsychotic naive or who did not tolerate and/or did not respond to previous antipsychotic treatments in an open-label pilot study. Fourteen patients with a mean (SD 12.4) age of 32.6 years were treated for a period of 6 weeks… CONTINUE READING


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